Chemistry:Salutaridine
From HandWiki
Salutaridine, also known as floripavine, is an alkaloid that is present in the morphinan alkaloid pathway of opium poppy, Papaver somniferum.
Biosynthesis
It is produced by the enzyme salutaridine synthase that catalyzes the chemical reaction from its precursor (R)-reticuline:[1][2]
The enzyme uses reduced nicotinamide adenine dinucleotide phosphate (NADPH) as its cofactor.
Salutaridine is converted to salutaridinol by the enzyme salutaridine reductase (NADPH).[3]
References
- ↑ Enzyme 1.14.19.67 at KEGG Pathway Database.
- ↑ "Formation of salutaridine from (R)-reticuline by a membrane-bound cytochrome P-450 enzyme from Papaver somniferum". Phytochemistry 32: 79–86. 1993. doi:10.1016/0031-9422(92)80111-Q.
- ↑ "Purification and characterization of salutaridine:NADPH 7-oxidoreductase from Papaver somniferum". Phytochemistry 34 (1): 125–132. 1993. doi:10.1016/S0031-9422(00)90793-3. Bibcode: 1993PChem..34..125G.
 |  |
