Chemistry:Securinine
From HandWiki
Short description: Chemical compound
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| Formula | C13H15NO2 |
| Molar mass | 217.268 g·mol−1 |
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Securinine is an alkaloid found in Securinega suffruticosa[1] and Phyllanthus niruri.[2]
Pharmacology
Securinine has pro-convulsant effects[3][4] and it has a strong spastic effect, similar to the actions of strychnine.[5]
Securinine is a GABA-A antagonist.[6][7]
See also
References
- ↑ "Securinine". Natural Small Molecule Drugs from Plants. Springer Singapore. 2018. pp. 325–330. doi:10.1007/978-981-10-8022-7_54. ISBN 978-981-10-8021-0.
- ↑ "Phyllanthus amarus: ethnomedicinal uses, phytochemistry and pharmacology: a review". Journal of Ethnopharmacology 138 (2): 286–313. November 2011. doi:10.1016/j.jep.2011.09.040. PMID 21982793.
- ↑ "[Central convulsive action of l-securinine]". Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica 7 (1): 9–12. January 1986. PMID 2876581.
- ↑ "[The adverse effects of the preparations of the active principles of Chinese herbal drugs]". Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica 18 (7): 387–391. July 1993. PMID 8267848.
- ↑ "Unique indolizidine alkaloid securinine is a promising scaffold for the development of neuroprotective and antitumor drugs". RSC Advances 11 (31): 19185–19195. May 2021. doi:10.1039/D1RA02558A. PMID 35478659. Bibcode: 2021RSCAd..1119185K.
- ↑ "Securinine". PubChem, US National Library of Medicine. 2020-07-04. https://pubchem.ncbi.nlm.nih.gov/compound/Securinine.
- ↑ "Securinine alkaloids: a new class of GABA receptor antagonist". Brain Research 330 (1): 135–140. March 1985. doi:10.1016/0006-8993(85)90014-9. PMID 2985189.
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