Chemistry:Sialyl-Lewis A

Sialyl-Lewis A

Identifiers
CAS Number	92448-22-1
3D model (JSmol)	Interactive image
MeSH	sialyl+Lewis+A
SMILES O=C(O)[C@@]1(O[C@H]2[C@@H](O)[C@@H](CO)O[C@@H](O[C@H]3[C@H](O[C@H]4[C@@H](O)[C@H](O)[C@H](O)[C@H](C)O4)[C@@H](CO)OC(O)[C@@H]3NC(C)=O)[C@@H]2O)C[C@H](O)[C@@H](NC(C)=O)[C@H]([C@H](O)[C@H](O)CO)O1
Properties
Chemical formula	C31H52N2O23
Molar mass	820.748 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Tracking categories (test):

• SizeSet

Sialyl-Lewis^A, also known as sialyl Le^A and SLe^A, is a tetrasaccharide carbohydrate with the sequence Neu5Acα2-3Galβ1-3[Fucα1-4]GlcNAcβ- that is usually attached to O-glycans on the surface of cells. It is known to play a vital role in cell-to-cell recognition processes.

Occurrence of the Sialyl-Lewis^A antigen, detected with the CA19-9 antibody, is highly correlated advanced epithelial cancers, such as stage III and stage IV colorectal cancers.

See also

• Sialyl lewis x
• Lewis A

Sources

• Essentials of Glycobiology 3rd Edition, Chapter 14: "Structures Common to Different Glycans" https://www.ncbi.nlm.nih.gov/books/NBK453042/#_Ch14_s2_