Chemistry:Streptolydigin
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Short description: Chemical compound
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| Formula | C32H44N2O9 |
| Molar mass | 600.709 g·mol−1 |
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Streptolydigin (Stl) is an antibiotic that works by inhibiting nucleic acid chain elongation by binding to RNA polymerase, thus inhibiting RNA synthesis inside a cell.[1][2][3] Streptolydigin inhibits bacterial RNA polymerase, but not eukaryotic RNA polymerase.[4] It has antibacterial activity against a number of Gram positive bacteria.[citation needed]
References
- ↑ "Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation". Cell 122 (4): 541–52. August 2005. doi:10.1016/j.cell.2005.07.017. PMID 16122422.
- ↑ "Structural basis of transcription inhibition by antibiotic streptolydigin". Molecular Cell 19 (5): 655–66. September 2005. doi:10.1016/j.molcel.2005.07.020. PMID 16167380.
- ↑ "Structural basis for substrate loading in bacterial RNA polymerase". Nature 448 (7150): 163–8. July 2007. doi:10.1038/nature05931. PMID 17581591. Bibcode: 2007Natur.448..163V.
- ↑ "Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation". Cell 122 (4): 541–52. August 2005. doi:10.1016/j.cell.2005.07.017. PMID 16122422.
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