Chemistry:Stress dose
From HandWiki
Perioperative stress dose of steroids to mitigate this rare but potentially fatal complications of perioperative use of steroid such as full-blown adrenal crisis in the perioperative period due to the secondary adrenal insufficiency. Various exogenous steroid preparations are used for a wide range of indications.[1]
Stress doses
Emergency corticosteroid supplementation in patients taking exogenous corticosteroids:[2]
| Category | Initial | Subsequent |
|---|---|---|
| Minor procedure or surgery under local anesthesia (e.g., inguinal hernia repair) | No extra supplementation is necessary | Continue normal dosing |
| Moderate surgical stress (e.g., lower extremity revascularization, total joint replacement) | 50 mg hydrocortisone IV | 25 mg of hydrocortisone every eight hours for 24 hours. Resume usual dose thereafter. |
| Major surgical stress (eg, esophagogastrectomy, total proctocolectomy, open heart surgery) | 100 mg hydrocortisone IV | 50 mg every eight hours for 24 hours. Taper dose by half per day to maintenance level. |
Pediatric doses
Emergent intramuscular dosing can be given if child is not tolerating oral medications or unable to get IV within 15 minutes. IM hydrocortisone sodium succinate doses are:[3]
- 25 mg for child 3 years and younger
- 50 mg for children >3 yrs – 12 years
- 100 mg for children 12 years and older.
References
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