Chemistry:TC-G 1005
From HandWiki
| File:TC-G1005 structure.png | |
| Identifiers | |
|---|---|
| |
| CAS Number | |
| PubChem CID | |
| ChemSpider | |
| ChEMBL | |
| Chemical and physical data | |
| Formula | C25H25N3O2 |
| Molar mass | 399.494 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
TC-G 1005 is an experimental drug which acts as a potent and selective agonist for the G protein-coupled bile acid receptor (GPBAR1/TGR5). It is used for studying the function of this receptor, and has been found to induce secretion of glucagon-like peptide-1 and reduce blood glucose levels.[1][2]
References
- ↑ "Design, synthesis, and antidiabetic activity of 4-phenoxynicotinamide and 4-phenoxypyrimidine-5-carboxamide derivatives as potent and orally efficacious TGR5 agonists". Journal of Medicinal Chemistry 55 (23): 10475–10489. December 2012. doi:10.1021/jm301071h. PMID 23148522.
- ↑ "Bile acids inhibit cholinergic constriction in proximal and peripheral airways from humans and rodents". American Journal of Physiology. Lung Cellular and Molecular Physiology 318 (2): L264–L275. February 2020. doi:10.1152/ajplung.00242.2019. PMID 31800261.
 |  |
