Chemistry:TC-N 22A
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| Formula | C14H13N5S |
| Molar mass | 283.35 g·mol−1 |
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TC-N 22A is an experimental drug that is a positive allosteric modulator for the glutamate receptor mGluR4. It was developed as a potential medication for the treatment of Parkinson's disease, and has also been used as a lead compound for the development of further derivatives.[1][2][3]
References
- ↑ "Tricyclic thiazolopyrazole derivatives as metabotropic glutamate receptor 4 positive allosteric modulators". Journal of Medicinal Chemistry 54 (14): 5070–5081. July 2011. doi:10.1021/jm200290z. PMID 21688779.
- ↑ "Overlapping binding sites drive allosteric agonism and positive cooperativity in type 4 metabotropic glutamate receptors". FASEB Journal 29 (1): 116–130. January 2015. doi:10.1096/fj.14-257287. PMID 25342125.
- ↑ "Synthesis and evaluation of a F-18 labeled tricyclic thiazolopyrazole derivative for imaging of metabotropic glutamate receptor 4 (mGluR4).". Journal of Nuclear Medicine 61 (supplement 1): 1031. 2020. ISSN 2159-662X.
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