Chemistry:TC-O 9311
From HandWiki
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| Formula | C20H19N3O4 |
| Molar mass | 365.389 g·mol−1 |
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TC-O 9311 is a chemical compound which acts as a small-molecule agonist of the previously orphan receptor GPR139.[1] It has been used to investigate the structure and function of the GPR139 receptor, and its interactions with other receptors with which it is co-expressed in the body such as the dopamine D2 receptor and the melanocortin receptors.[2][3][4]
References
- ↑ "Identification and SAR of Glycine Benzamides as Potent Agonists for the GPR139 Receptor". ACS Medicinal Chemistry Letters 6 (9): 1015–1018. September 2015. doi:10.1021/acsmedchemlett.5b00247. PMID 26396690.
- ↑ "Re-evaluation of Adrenocorticotropic Hormone and Melanocyte Stimulating Hormone Activation of GPR139 in Vitro". Frontiers in Pharmacology 9. 2018. doi:10.3389/fphar.2018.00157. PMID 29599718.
- ↑ "Mutagenesis of GPR139 reveals ways to create gain or loss of function receptors". Pharmacology Research & Perspectives 7 (1). February 2019. doi:10.1002/prp2.466. PMID 30774960.
- ↑ "GPR139 and Dopamine D2 Receptor Co-express in the Same Cells of the Brain and May Functionally Interact". Frontiers in Neuroscience 13. 2019. doi:10.3389/fnins.2019.00281. PMID 30971885.
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