Chemistry:Taltirelin
From HandWiki
Short description: Chemical compound
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| Other names | (4S)-N-[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-3-(3H-imidazol-4-yl)-1-oxopropan-2-yl]-1-methyl-2,6-dioxo-1,3-diazinane-4-carboxamide |
| AHFS/Drugs.com | International Drug Names |
| Routes of administration | Oral |
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| Formula | C17H31N7O9 |
| Molar mass | 477.475 g·mol−1 |
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Taltirelin (marketed under the tradename Ceredist) is a thyrotropin-releasing hormone (TRH) analog, which mimics the physiological actions of TRH, but with a much longer half-life and duration of effects,[1] and little development of tolerance following prolonged dosing.[2] It has nootropic,[3] neuroprotective[4] and analgesic effects.[5]
Taltirelin is primarily being researched for the treatment of spinocerebellar ataxia; limited research has also been carried out with regard to other neurodegenerative disorders, e.g., spinal muscular atrophy.[6][7][8]
References
- ↑ "Effects of taltirelin hydrate (TA-0910), a novel thyrotropin-releasing hormone analog, on in vivo dopamine release and turnover in rat brain". Arzneimittel-Forschung 48 (4): 353–9. April 1998. PMID 9608876.
- ↑ "Lack of behavioral tolerance by repeated treatment with taltirelin hydrate, a thyrotropin-releasing hormone analog, in rats". Pharmacology, Biochemistry, and Behavior 82 (4): 646–51. December 2005. doi:10.1016/j.pbb.2005.11.004. PMID 16368129.
- ↑ "[Synthesis and pharmacological action of TRH analog peptide (Taltirelin)]". Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica 110 Suppl 1: 33P–38P. October 1997. doi:10.1254/fpj.110.supplement_33. PMID 9503402.
- ↑ "Neuroprotective effect and brain receptor binding of taltirelin, a novel thyrotropin-releasing hormone (TRH) analogue, in transient forebrain ischemia of C57BL/6J mice". Life Sciences 72 (4–5): 601–7. December 2002. doi:10.1016/S0024-3205(02)02268-3. PMID 12467901.
- ↑ "The synthetic TRH analogue taltirelin exerts modality-specific antinociceptive effects via distinct descending monoaminergic systems". British Journal of Pharmacology 150 (4): 403–14. February 2007. doi:10.1038/sj.bjp.0707125. PMID 17220907.
- ↑ "Efficacy of thyrotropin-releasing hormone in the treatment of spinal muscular atrophy". Journal of Child Neurology 9 (3): 287–9. July 1994. doi:10.1177/088307389400900313. PMID 7930408.
- ↑ "A study of thyrotropin-releasing hormone for the treatment of spinal muscular atrophy: a preliminary report". American Journal of Physical Medicine & Rehabilitation 79 (5): 435–40. 2000. doi:10.1097/00002060-200009000-00005. PMID 10994885.
- ↑ "Oral administration of the thyrotropin-releasing hormone (TRH) analogue, taltireline hydrate, in spinal muscular atrophy". Journal of Child Neurology 24 (8): 1010–2. August 2009. doi:10.1177/0883073809333535. PMID 19666885.
External links
- (in Japanese) Ceredist セレジスト錠 (PDF) Mitsubishi Tanabe Pharma. October 2007.
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