Chemistry:Tinosporide

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Tinosporide is a chemical compound classified as a diterpenoid and a furanolactone. It was first isolated from the plant Tinospora cordifolia, from which it derives its name.[1][2] It has since been found in other plants of the genus Tinospora, such as Tinospora glabra.[3] [4] [5]

Because Tinospora cordifolia has been used in traditional herbal medicine, there has been research directed at exploring the potential pharmacology of tinosporide and related compounds.[6]

Other diterpenoid furanolactones with a similar structure include columbin, palmarin, and chasmanthin.

  • Columbin
    Columbin
  • Palmarin
    Palmarin
  • Chasmanthin
    Chasmanthin
  1. ↑ Swaminathan, K.; Sinha, U. C.; Bhatt, R. K.; Sabata, B. K.; Tavale, S. S. (1989). "Structure of tinosporide, a diterpenoid furanolactone from Tinospora cordifolia Miers". Acta Crystallographica Section C 45 (1): 134–136. doi:10.1107/s0108270188009953. PMID 2610955. Bibcode: 1989AcCrC..45..134S. 
  2. ↑ Sharma, Priyanka; Dwivedee, Bharat P.; Bisht, Dheeraj; Dash, Ashutosh K.; Kumar, Deepak (2019). "The chemical constituents and diverse pharmacological importance of Tinospora cordifolia". Heliyon 5 (9). doi:10.1016/j.heliyon.2019.e02437. PMID 31701036. Bibcode: 2019Heliy...502437S. 
  3. ↑ "Isolation and Characterisation of clerodane diterpenoids from the traditional medicinal plant -Tinospora glabra (Burm. f.) Merrill". https://www.researchgate.net/publication/304379324. 
  4. ↑ Girme, Aboli; Saste, Ganesh; Singh, Ruchi; Mirgal, Amit; Ingavale, Rajnita; Balasubramaniam, Arun Kumar; Ghoshal, Sautik; Ghule, Chetana et al. (2022). "Quantitative and rapid quality assessment methods for the multi-class bioactive constituents of Tinospora cordifolia using high-performance liquid and thin layer chromatography analysis with tandem mass spectrometry characterization". Separation Science Plus 5 (8): 378–392. doi:10.1002/sscp.202200048. https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/abs/10.1002/sscp.202200048. 
  5. ↑ Adib, Mohiminul; Islam, Rashedul; Ahsan, Monira; Rahman, Arifur; Hossain, Mahmud; Rahman, Md Mustafizur; Alshehri, Sultan M.; Kazi, Mohsin et al. (2021). "Cholinesterase inhibitory activity of tinosporide and 8-hydroxytinosporide isolated from Tinospora cordifolia: In vitro and in silico studies targeting management of Alzheimer's disease". Saudi Journal of Biological Sciences 28 (7): 3893–3900. doi:10.1016/j.sjbs.2021.03.063. PMID 34220245. Bibcode: 2021SJBS...28.3893A. 
  6. ↑ Pathak, Ashish K.; Jain, Dharam C.; Sharma, Ram P. (1995). "Chemistry and Biological Activities of the Genera Tinospora". International Journal of Pharmacognosy 33 (4): 277–287. doi:10.3109/13880209509065379. 




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