Chemistry:Tivoxavir marboxil

Short description: Investigational drug

Tivoxavir marboxil

Clinical data
Other names	TRX-100, AV5124, viroksavir, viroxavir
Identifiers
IUPAC name [(3R)-2-[(10S)-6,7-difluoro-5,10-dihydrothieno[3,2-c][2]benzothiepin-10-yl]-9,12-dioxo-5-oxa-1,2,8-triazatricyclo[8.4.0.03,8]tetradeca-10,13-dien-11-yl]oxymethyl methyl carbonate
CAS Number	2417851-93-3
PubChem CID	155280058
UNII	8P73TA5CLC
Chemical and physical data
Formula	C25H21F2N3O7S2
Molar mass	577.57 g·mol−1
3D model (JSmol)	Interactive image
SMILES COC(=O)OCOC1=C2C(=O)N3CCOC[C@H]3N(N2C=CC1=O)[C@H]4C5=C(CSC6=C4SC=C6)C(=C(C=C5)F)F
InChI InChI=InChI=1S/C25H21F2N3O7S2/c1-34-25(33)37-12-36-22-16(31)4-6-29-21(22)24(32)28-7-8-35-10-18(28)30(29)20-13-2-3-15(26)19(27)14(13)11-39-17-5-9-38-23(17)20/h2-6,9,18,20H,7-8,10-12H2,1H3/t18-,20+/m1/s1 Key:JFAAVTYPCCKWCW-QUCCMNQESA-N

Tivoxavir marboxil is an investigational new drug that is being evaluated by Traws Pharma, Inc. for the treatment of influenza. It is a cap-dependent endonuclease inhibitor.

Chemistry

Tivoxavir marboxil the prodrug form of tivoxavir. The carbonate containing sidechain (marboxil) is cleaved enzymatically to yield the active form of the drug tivoxavir.