Chemistry:VVD-118313
From HandWiki
VVD-118313 is a chemical compound which acts as a potent and selective negative allosteric modulator of JAK1, and was developed for research into the treatment of inflammatory diseases, especially chronic inflammation involved in the development of cancer.[1][2][3][4]
See also
References
- ↑ "Selective inhibitors of JAK1 targeting an isoform-restricted allosteric cysteine". Nature Chemical Biology 18 (12): 1388–1398. December 2022. doi:10.1038/s41589-022-01098-0. PMID 36097295.
- ↑ "Aiming for the pocket". Nature Chemical Biology 18 (12): 1296–1297. December 2022. doi:10.1038/s41589-022-01120-5. PMID 36097296.
- ↑ "Structural basis of Janus kinase trans-activation". Cell Reports 42 (3). March 2023. doi:10.1016/j.celrep.2023.112201. PMID 36867534.
- ↑ "Progress on the Pharmacological Targeting of Janus Pseudokinases". Journal of Medicinal Chemistry 66 (16): 10959–10990. August 2023. doi:10.1021/acs.jmedchem.3c00926. PMID 37578217.
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