Chemistry:Vesugen
From HandWiki
Vesugen (T-38) is a tripeptide with the sequence KED or Lys-Glu-Asp. It is one of a number of small peptides developed in Russia in the late 1990s and early 2000s[1] which are purported to have anti-aging effects.[2][3] Vesugen is claimed to stimulate proliferation and protein synthesis in fibroblast cells in the skin and to improve the appearance of skin,[4][5] as well as promoting neurotropic effects in brain tissue,[6][7][8] giving it a similar pharmacological profile to those claimed for the matrikine peptides produced by Western cosmetic skincare companies.
See also
References
- ↑ Khavinson VK, Grigor'ev EI, Malinin VV, Ryzhak GA, "Peptide enhancing resistance of capillaries, pharmaceutical composition based on thereof and method for its use", RU patent 2295970, issued 27 March 2007
- ↑ "Peptides tissue-specifically stimulate cell differentiation during their aging". Bulletin of Experimental Biology and Medicine 153 (1): 148–151. May 2012. doi:10.1007/s10517-012-1664-1. PMID 22808515.
- ↑ "Gene expression in human mesenchymal stem cell aging cultures: modulation by short peptides". Molecular Biology Reports 47 (6): 4323–4329. June 2020. doi:10.1007/s11033-020-05506-3. PMID 32399807.
- ↑ "Effect of bioregulatory tripeptides on the culture of skin cells from young and old rats". Bulletin of Experimental Biology and Medicine 152 (3): 357–359. January 2012. doi:10.1007/s10517-012-1527-9. PMID 22803085.
- ↑ "Peptide Regulation of Skin Fibroblast Functions during Their Aging In Vitro". Bulletin of Experimental Biology and Medicine 161 (1): 175–178. May 2016. doi:10.1007/s10517-016-3370-x. PMID 27259496.
- ↑ "Effect of short peptides on neuronal differentiation of stem cells". International Journal of Immunopathology and Pharmacology 33. 2019. doi:10.1177/2058738419828613. PMID 30791821.
- ↑ "Peptide KED: Molecular-Genetic Aspects of Neurogenesis Regulation in Alzheimer's Disease". Bulletin of Experimental Biology and Medicine 171 (2): 190–193. May 2021. doi:10.1007/s10517-021-05192-6. PMID 34173097.
- ↑ "Short Peptides Protect Fibroblast-Derived Induced Neurons from Age-Related Changes". International Journal of Molecular Sciences 25 (21). October 2024. doi:10.3390/ijms252111363. PMID 39518916.
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