Chemistry:Vinconate

From HandWiki

Vinconate is a synthetic vincamine analog used as a nootropic.[1]

Vinconate, even when systemically administered, enhances the endogenous release of dopamine in the striatum, probably via the stimulation of presynaptic muscarinic receptors.[2]

Synthesis

Synthesis:[3] Patent:[4]

References

  1. "A Review of Neuroprotective Agents". Frontiers in Medicinal Chemistry. 3. SAIF Zone: Bentham Science Publishers. 2010. pp. 182. ISBN 978-1-60805-206-6. https://books.google.com/books?id=yIo6nuJyqhcC&dq=Vinconate&pg=PA182. 
  2. Iino T, Katsura M, Kuriyama K. Effect of vinconate on the extracellular levels of dopamine and its metabolites in the rat striatum: microdialysis studies. Eur J Pharmacol. 1995 Nov 3;286(1):99-103. doi: 10.1016/0014-2999(95)00545-v. PMID: 8566157.
  3. Castaer, J.; Serradell, MN; Vinconate. Drugs Fut 1984, 9, 4, 283.
  4. Jean A. A. J. Hannart, U.S. Patent 4,200,638 (1980 to Omnium Chimique SA).