Chemistry:XF-73
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3D model (JSmol)
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PubChem CID
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| Properties | |
| C44H50Cl2N6O2 | |
| Molar mass | 765.82 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
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XF-73 (Exeporfinium chloride) is an experimental drug candidate. It is an anti-microbial that works via weakening bacteria cell walls.[1] It is a potential treatment for methicillin-resistant Staphylococcus aureus (MRSA) and possibly Clostridium difficile. It is being developed by Destiny Pharma Ltd.[2][3][4]
Structurally, it is a dicationic porphyrin.[5]
It has completed a phase I clinical trial for nasal decolonisation of MRSA—being tested against 5 bacterial strains. It seems unlikely to cause MRSA to develop resistance to it.[1][6]
In 2014, a phase 1 clinical trial for nasal administration was run.[7]
(As of June 2022), another phase 1 clinical trial (for nasal administration) completed recruiting in 2016 but no results have been posted.[8]
References
- ↑ 1.0 1.1 Neka Sehgal (20 September 2010). "Promising new drug XF-73 kills superbugs within 5 minutes". http://www.themoneytimes.com/featured/20100920/promising-new-drug-xf73-kills-superbugs-within-5-minutes-id-10129029.html.
- ↑ "XF-73". Destiny Pharma. 29 July 2016. http://www.destinypharma.com/xf73.shtml. (Shows molecular structure.)
- ↑ Miller, K.; Ooi, N.; Hobbs, J. K.; Rhys-Williams, W.; Love, W. G.; Hayter, I.; Katila, M.; Chopra, I. (19 April 2008). XF-73, a novel anti-staphylococcal antimicrobial with very rapid bactericidal activity. European Society of Clinical Microbiology and Infectious Diseases. http://www.blackwellpublishing.com/eccmid18/abstract.asp?id=68457.
- ↑ Mary Dejevsky (18 May 2008). "Scientists 'on brink of cure' for superbug". The Independent. https://www.independent.co.uk/news/science/scientists-on-brink-of-cure-for-superbug-830345.html.
- ↑ "XF series". Destiny Pharma. 29 July 2016. http://www.destinypharma.com/xfseries.shtml.
- ↑ Tom Chivers (18 May 2008). "MRSA: UK scientists 'close to a treatment". The Daily Telegraph. https://www.telegraph.co.uk/news/uknews/1981019/MRSA-UK-scientists-%27close-to-a-treatment%27.html.
- ↑ Study of the Nasal Decolonisation of Staphylococcus Aureus (SA) and the Safety and Tolerability of XF-73 Nasal Gel in Healthy Subjects
- ↑ Study of the Safety and Local Tolerability of Intranasal Gel Formulations of XF-73
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