Chemistry:YQ128
From HandWiki
YQ128 is an experimental drug which acts as an inhibitor of the NLRP3 inflammasome. It inhibits the release of interleukin-1β and interleukin-18 which is usually triggered by inflammatory stimuli, and so terminates the resulting signalling cascade. It has antiinflammatory effects and good brain penetration, and is being researched for potential applications in conditions such as Alzheimer's disease and traumatic brain injury.[1][2]
See also
- NP3-146
References
- ↑ "Discovery of Second-Generation NLRP3 Inflammasome Inhibitors: Design, Synthesis, and Biological Characterization". Journal of Medicinal Chemistry 62 (21): 9718–9731. November 2019. doi:10.1021/acs.jmedchem.9b01155. PMID 31626545.
- ↑ "Development of sulfonamide-based NLRP3 inhibitors: Further modifications and optimization through structure-activity relationship studies". European Journal of Medicinal Chemistry 238. August 2022. doi:10.1016/j.ejmech.2022.114468. PMID 35635948.
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