Chemistry:Yoda1
From HandWiki
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| Preferred IUPAC name
2-(5-{[(2,6-Dichlorophenyl)methyl]sulfanyl}-1,3,4-thiadiazol-2-yl)pyrazine | |
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3D model (JSmol)
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PubChem CID
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| Properties | |
| C13H8Cl2N4S2 | |
| Molar mass | 355.27 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| Infobox references | |
Yoda1 is a chemical compound which is the first agonist developed for the mechanosensitive ion channel PIEZO1. This protein is involved in regulation of blood pressure and red blood cell volume, and Yoda1 is used in scientific research in these areas.[1][2][3][4][5]
See also
References
- ↑ Syeda, Ruhma; Xu, Jie; Dubin, Adrienne E.; Coste, Bertrand; Mathur, Jayanti; Huynh, Truc; Matzen, Jason; Lao, Jianmin et al. (2015). "Chemical activation of the mechanotransduction channel Piezo1". eLife 4: e07369. doi:10.7554/eLife.07369. PMID 26001275.
- ↑ Cahalan, Stuart M.; Lukacs, Viktor; Ranade, Sanjeev S.; Chien, Shu; Bandell, Michael; Patapoutian, Ardem (2015). "Piezo1 links mechanical forces to red blood cell volume". eLife 4: e07370. doi:10.7554/eLife.07370. PMID 26001274.
- ↑ Wang, ShengPeng; Chennupati, Ramesh; Kaur, Harmandeep; Iring, Andras; Wettschureck, Nina; Offermanns, Stefan (2016). "Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release". Journal of Clinical Investigation 126 (12): 4527–4536. doi:10.1172/JCI87343. PMID 27797339.
- ↑ Rapetti-Mauss, Raphaël; Picard, Véronique; Guitton, Corinne; Ghazal, Khaldoun; Proulle, Valérie; Badens, Catherine; Soriani, Olivier; Garçon, Loïc et al. (2017). "Red blood cell Gardos channel (KCNN4): The essential determinant of erythrocyte dehydration in hereditary xerocytosis". Haematologica 102 (10): e415–e418. doi:10.3324/haematol.2017.171389. PMID 28619848.
- ↑ Gnanasambandam, R.; Gottlieb, P. A.; Sachs, F. (2017). "The Kinetics and the Permeation Properties of Piezo Channels". in Gottlieb, Philip A.. Piezo Channels. Current Topics in Membranes. 79. Academic Press. pp. 275–307. doi:10.1016/bs.ctm.2016.11.004. ISBN 978-0-12-809389-4.
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