Chemistry:Z583
From HandWiki
Z583 (GLXC-26150) is a chemical compound which acts as a potent and highly selective inhibitor of JAK3, and was developed for the treatment of rheumatoid arthritis.[1][2][3][4][5]
See also
References
- ↑ "Recent developments in anticancer kinase inhibitors based on the pyrazolo[3,4-dpyrimidine scaffold"]. RSC Medicinal Chemistry 11 (10): 1112–1135. October 2020. doi:10.1039/d0md00227e. PMID 33479617.
- ↑ "A highly selective JAK3 inhibitor is developed for treating rheumatoid arthritis by suppressing γc cytokine-related JAK-STAT signal". Science Advances 8 (33). August 2022. doi:10.1126/sciadv.abo4363. PMID 35984890. Bibcode: 2022SciA....8O4363C.
- ↑ "Novel JAK3-specific inhibitor safe and effective in mouse RA model". Nature Reviews. Rheumatology 18 (10): 551. October 2022. doi:10.1038/s41584-022-00839-8. PMID 36071217.
- ↑ "Evolving cognition of the JAK-STAT signaling pathway: autoimmune disorders and cancer". Signal Transduction and Targeted Therapy 8 (1). May 2023. doi:10.1038/s41392-023-01468-7. PMID 37208335.
- ↑ "Allosteric TYK2 inhibition: redefining autoimmune disease therapy beyond JAK1-3 inhibitors". eBioMedicine 97. November 2023. doi:10.1016/j.ebiom.2023.104840. PMID 37863021.
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