Chemistry:Zimlovisertib
From HandWiki
Zimlovisertib (PF-06650833) is a drug which acts as a selective inhibitor of the enzyme Interleukin-1 receptor-associated kinase 4 (IRAK-4). It has antiinflammatory effects and has been trialed for various indications including hidradenitis suppurativa and treatment of COVID-19 infection, and while it has not been adopted into clinical use it continues to be used for research in this area.[1][2][3]
See also
- Emavusertib
- Zabedosertib
References
- ↑ "Binding Energy Partition of Promising IRAK-4 Inhibitor (Zimlovisertib) for the Treatment of COVID-19 Pneumonia". ChemPhysChem 23 (24). December 2022. doi:10.1002/cphc.202200455. PMID 36044560.
- ↑ "Brepocitinib, Zimlovisertib, and Ropsacitinib in Hidradenitis Suppurativa". NEJM Evidence 3 (3). March 2024. doi:10.1056/EVIDoa2300155. PMID 38335032.
- ↑ "In Retrospect: Root-Cause Analysis of Structure-Activity Relationships in IRAK4 Inhibitor Zimlovisertib (PF-06650833)". ACS Medicinal Chemistry Letters 15 (4): 540–545. April 2024. doi:10.1021/acsmedchemlett.4c00036. PMID 38628800.
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