Chemistry:Zosurabalpin
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Short description: Investigational antibiotic
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| Other names | N2.2.2.1,3-anhydro(N2-[(2-([2-(aminomethyl)-4'-carboxy[1,1'-biphenyl]-3-yl]sulfanyl)pyridin-3-yl)methyl]-L-ornithyl-L-lysyl-N-methyl-L-tryptophan |
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| Formula | C43H50N8O5S |
| Molar mass | 790.98 g·mol−1 |
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Zosurabalpin (RG6006, Abx-MCP, Ro7223280) is an experimental antibiotic developed in a collaboration between the pharmaceutical company Roche and scientists from Harvard University, for the treatment of carbapenem-resistant Acinetobacter baumannii (CRAB). It targets a lipopolysaccharide transporter.[1] It works by recognizing a composite binding site made up of both the Lpt transporter and its LPS substrate.[2] The chemical family to which it belongs was first disclosed in 2019, but the particular structure of RG6006 remained confidential until publication of the testing results in 2023.[3][4][5]
See also
- Clovibactin
- Novobiocin
- Teixobactin
References
- ↑ "A novel antibiotic class targeting the lipopolysaccharide transporter". Nature 625 (7995): 566–571. January 2024. doi:10.1038/s41586-023-06873-0. PMID 38172634.
- ↑ "A new antibiotic traps lipopolysaccharide in its intermembrane transporter". Nature 625 (7995): 572–577. January 2024. doi:10.1038/s41586-023-06799-7. PMID 38172635.
- ↑ Bleicher K, Cheang D, Di Giorgio P, Hu T, Jenny C, Mattei P, Schmitz P, Stoll T, "Peptide macrocycles against acinetobacter baumannii.", US patent 20190321440A1, issued 21 November 2023
- ↑ "2109. In vitro and in vivo Killing Kinetics of Zosurabalpin (RG6006) Against Acinetobacter baumannii.". Open Forum Infectious Diseases. 10. Oxford University Press. December 2023. doi:10.1093/ofid/ofad500.1733.
- ↑ "Evaluating the innovative potential of the global antibacterial pipeline". Clinical Microbiology and Infection. October 2023. doi:10.1016/j.cmi.2023.09.024. PMID 37805036.
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