Company:Sinovac Biotech

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Short description: Chinese biopharmaceutical company

[ ⚑ ] 40°01′52″N 116°18′01″E / 40.031°N 116.3003°E / 40.031; 116.3003

Sinovac Biotech
TypePublic
NASDAQ: SVA
(American Depository Receipts)
Founded1999; 25 years ago (1999)
FounderYin Weidong[1]
Headquarters39 Shang Di West Road, Haidian District,
Beijing
,
China
Number of employees
910[2]
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Websitesinovac.com

Sinovac Biotech Ltd. (Chinese: 科兴控股生物技术有限公司, NASDAQ: SVA) is a Chinese biopharmaceutical company that focuses on the research, development, manufacture, and commercialization of vaccines that protect against human infectious diseases. The company is based in Haidian District, Beijing in China.[3] The company is listed on the NASDAQ but the exchange halted Sinovac's trading in February 2019 due to a proxy fight.[4][5] The company has faced bribery probes in China.[4]

Vaccines

Sinovac's commercialized vaccines include CoronaVac (COVID-19 vaccine), Inlive (Enterovirus 71 vaccine), Anflu (influenza vaccine), Healive (hepatitis A vaccine), varicella vaccine and mumps vaccine.[6]

COVID-19 vaccine development

Main page: Medicine:CoronaVac

CoronaVac is an inactivated virus COVID-19 vaccine developed by Sinovac.[7] It has been in Phase III clinical trials in Brazil ,[8] Chile ,[9] Indonesia,[10] Philippines ,[11] and Turkey.[12]

It relies on traditional technology similar to BBIBP-CorV and BBV152, otherwise known as inactivated-virus COVID-19 vaccines in Phase III trials.[13] CoronaVac does not need to be frozen, and both the vaccine and raw material for formulating the new doses could be transported and refrigerated at 2–8 °C (36–46 °F), temperatures at which flu vaccines are kept.[14]

A real-world study of ten millions of Chileans who received CoronaVac found it 66% effective against symptomatic COVID-19, 88% against hospitalization, 90% against ICU admissions, and 86% against deaths.[15] In Brazil, after 75% of the population in Serrana, São Paulo received CoronaVac, preliminary results show deaths fell by 95%, hospitalizations by 86%, and symptomatic cases by 80%.[16][17] In Indonesia, real world data from 128,290 healthcare workers showed 94% protection against symptomatic infection by the vaccine, beating results in clinical trials.[18]

Phase III results from Turkey published in The Lancet showed an efficacy of 84% based on 10,218 participants in the trials.[19][20] Phase III results from Brazil previously showed 50.7% efficacy at preventing symptomatic infections and 83.7% effective in preventing mild cases needing treatment. Efficacy against symptomatic infections increased to 62.3% with an interval of 21 days or more between the doses.[21]

CoronaVac is being used in vaccination campaigns in various countries in Asia,[22][23][24] South America,[25][26][27] North America,[28][29][30] and Europe.[31][32][33] By April 2021, Sinovac had a production capacity of two billion doses a year[34] and had delivered 600 million total doses.[35] It is currently being manufactured at several facilities in China,[34] Brazil,[36] and Egypt.[37] On 1 June 2021, the World Health Organization (WHO) validated the vaccine for emergency use.[38][39][40] Sinovac has signed purchase agreements for 380 million doses from COVAX.[41]

See also

References

  1. ↑ "China's Vaccine Front-Runner Aims to Beat Covid the Old-Fashioned Way" (in en). 24 August 2020. https://www.bloomberg.com/news/articles/2020-08-24/coronavirus-vaccine-china-s-covid-front-runner-uses-brute-force-approach. 
  2. ↑ "Sinovac Biotech Ltd". bloomberg.com. https://www.bloomberg.com/profile/company/SVA:US. 
  3. ↑ "Home (English)". Sinovac. http://www.sinovac.com/. "Add: No. 39 Shangdi Xi Road, Haidian District, Beijing, P.R.C. 100085"  - Chinese address: "地址：北京市海淀区上地西路39号北大生物城"
  4. ↑ 4.0 4.1 Dou, Eva (December 4, 2020). "As China nears a coronavirus vaccine, bribery cloud hangs over drugmaker Sinovac" (in en-US). The Washington Post. ISSN 0190-8286. https://www.washingtonpost.com/world/asia_pacific/coronavirus-vaccine-china-bribery-sinovac/2020/12/04/7c09ae68-28c6-11eb-9c21-3cc501d0981f_story.html. 
  5. ↑ Levine, Matt (May 22, 2020). "A Vaccine With a Poison Pill". Bloomberg News. https://www.bloomberg.com/news/newsletters/2020-05-22/money-stuff-a-vaccine-with-a-poison-pill. 
  6. ↑ "Vaccines". http://www.sinovac.com/product/product.php?class2=162&lang=en. 
  7. ↑ Nidhi Parekh (22 July 2020). "CoronaVac: A COVID-19 Vaccine Made From Inactivated SARS-CoV-2 Virus". https://fancycomma.com/2020/07/22/coronavac-inactivated-covid19-vaccine/. 
  8. ↑ "New coronavirus vaccine trials start in Brazil". 21 July 2020. https://apnews.com/article/f946b044e0b507616aca201375e46571. 
  9. ↑ "Chile initiates clinical study for COVID-19 vaccine". Chile Reports. 4 August 2020. https://chilereports.cl/en/news/2020/08/04/chile-initiates-clinical-study-for-covid-19-vaccine. 
  10. ↑ "248 volunteers have received Sinovac vaccine injections in Bandung". Antara News. 30 August 2020. https://en.antaranews.com/news/155398/248-volunteers-have-received-sinovac-vaccine-injections-in-bandung. 
  11. ↑ "DOH eyes 5 hospitals for Sinovac vaccine Phase 3 clinical trial". PTV News. 16 September 2020. https://ptvnews.ph/doh-eyes-5-hospitals-for-sinovac-vaccine-phase-3-clinical-trial/. 
  12. ↑ "Turkey begins phase three trials of Chinese Covid-19 vaccine". TRT World News. 1 September 2020. https://www.trtworld.com/turkey/turkey-begins-phase-three-trials-of-chinese-covid-19-vaccine-39806. 
  13. ↑ Zimmer, Carl; Corum, Jonathan; Wee, Sui-Lee. "Coronavirus Vaccine Tracker" (in en-US). The New York Times. ISSN 0362-4331. https://www.nytimes.com/interactive/2020/science/coronavirus-vaccine-tracker.html. 
  14. ↑ "CoronaVac: Doses will come from China on nine flights and can..." (in ar). 2020-11-01. https://alkhaleejtoday.co/international/5246732/CoronaVac-Doses-will-come-from-China-on-nine-flights-and-can.html. 
  15. ↑ "Effectiveness of an Inactivated SARS-CoV-2 Vaccine in Chile". The New England Journal of Medicine 385 (10): 875–884. July 2021. doi:10.1056/NEJMoa2107715. PMID 34233097. 
  16. ↑ "Sinovac vaccine restores a Brazilian city to near normal". 2021-06-01. https://www.ctvnews.ca/health/coronavirus/sinovac-vaccine-restores-a-brazilian-city-to-near-normal-1.5451755. 
  17. ↑ "Brazil's Experiment to Vaccinate Town With Chinese CoronaVac Reduced Covid-19 Deaths by 95%". The Wall Street Journal. 2021-05-31. ISSN 0099-9660. https://www.wsj.com/articles/brazils-experiment-to-vaccinate-town-with-chinese-coronavac-reduced-covid-19-deaths-by-95-11622479864. 
  18. ↑ "China Sinovac Shot Seen Highly Effective in Real World Study". 12 May 2021. https://www.msn.com/en-us/money/other/chinas-sinovac-shot-found-highly-effective-in-real-world-study/ar-BB1gCGwD. 
  19. ↑ "Efficacy and safety of an inactivated whole-virion SARS-CoV-2 vaccine (CoronaVac): interim results of a double-blind, randomised, placebo-controlled, phase 3 trial in Turkey" (in English). The Lancet 398 (10296): 213–222. 8 July 2021. doi:10.1016/S0140-6736(21)01429-X. ISSN 0140-6736. PMID 34246358. 
  20. ↑ Evidence Assessment: Sinovac/CoronaVac COVID-19 vaccine (PDF) (Presentation). World Health Organization. 29 April 2021. Retrieved 10 July 2021.
  21. ↑ "Estudo clínico que comprova maior eficácia da Coronavac é enviado para Lancet" (in Portuguese). CNN Brasil (São Paulo). 2021-04-11. https://www.cnnbrasil.com.br/saude/2021/04/11/estudo-clinico-que-comprova-maior-eficacia-da-coronavac-e-enviado-para-lancet. 
  22. ↑ TARIGAN, EDNA; MILKO, VICTORIA (13 January 2021). "Indonesia starts mass COVID vaccinations over vast territory". https://apnews.com/article/asia-pacific-indonesia-coronavirus-pandemic-joko-widodo-3ff30c85dc6943e2a06db470a9d04931. 
  23. ↑ "Thailand Kicks Off Covid-19 Vaccine Program With Sinovac Shots" (in en). Bloomberg.com. https://www.bloomberg.com/news/articles/2021-02-28/thailand-kicks-off-covid-19-vaccine-program-with-sinovac-shots. 
  24. ↑ "China approves Sinovac vaccines for general public use" (in en). 6 February 2021. https://www.scmp.com/news/china/science/article/3120855/covid-19-china-approves-sinovac-vaccine-general-public-use. 
  25. ↑ Rochabrun, Marcelo. "Brazil health ministry says plans to order 30 million more Coronavac doses | The Chronicle Herald" (in en). http://www.thechronicleherald.ca/news/world/brazil-health-ministry-says-plans-to-order-30-million-more-coronavac-doses-554373/. 
  26. ↑ Miranda, Natalia A. Ramos (28 January 2021). "Chile receives two million-dose first delivery of Sinovac COVID-19 vaccine" (in en). Reuters. https://www.reuters.com/article/us-health-coronavirus-chile-sinovac-idUSKBN29X282. 
  27. ↑ "BNamericas - Uruguay prepares to launch COVID-19 vaccinat...". https://www.bnamericas.com/en/news/uruguay-prepares-to-launch-covid-19-vaccination-scheme-as-china-jabs-arrive. 
  28. ↑ "Venustiano Carranza next up for Covid vaccination in Mexico City". 2021-03-15. https://mexiconewsdaily.com/news/coronavirus/venustiano-carranza-next-up-for-covid-vaccination-in-mexico-city/. 
  29. ↑ "Anticovid vaccines run out as Dominican Republic awaits arrival of more doses" (in en). https://dominicantoday.com/dr/covid-19/2021/03/08/anticovid-vaccines-run-out-as-dominican-republic-awaits-arrival-of-more-doses/. 
  30. ↑ "Llegan a El Salvador un millón de dosis de la vacuna china CoronaVac contra el covid-19 de la farmacéutica Sinovac" (in es-ES). https://www.laprensagrafica.com/elsalvador/Llegan-a-El-Salvador-un-millon-de-dosis-de-la-vacuna-china-contra-el-covid-19-de-la-farmaceutica-Sinovac-20210328-0004.html. 
  31. ↑ "Turkey aims to vaccinate 60 percent of population: Minister – Turkey News" (in en). https://www.hurriyetdailynews.com/turkey-targets-to-vaccinate-60-of-population-health-minister-162317. 
  32. ↑ "Vaccination with CoronaVac launched in Ukraine on April 13 – Health minister" (in en). https://www.unian.info/society/covid-19-vaccination-with-coronavac-launched-in-ukraine-on-april-13-health-minister-11386060.html. 
  33. ↑ Semini, Llazar. "Albania starts mass COVID vaccinations before tourist season" (in en). https://abcnews.go.com/Business/wireStory/albania-starts-mass-covid-vaccinations-tourist-season-76733128. 
  34. ↑ 34.0 34.1 Liu, Roxanne (2021-04-02). "China Sinovac says it reached two billion doses annual capacity for COVID-19 vaccine" (in en). Reuters. https://www.reuters.com/article/us-health-coronavirus-vaccine-sinovac-idUSKBN2BP07G. 
  35. ↑ Nebehay, Stephanie (2021-06-01). "WHO approves Sinovac COVID vaccine, the second Chinese-made dose listed". Reuters (Geneva). https://www.reuters.com/article/us-health-coronavirus-who-sinovac/who-approves-sinovac-covid-vaccine-the-second-chinese-made-dose-listed-idUSKCN2DD3V5. 
  36. ↑ "Chinese vaccine draws demand across Latin America, say Brazilian officials" (in en). Reuters. 10 December 2020. https://www.reuters.com/article/health-coronavirus-brazil-idUSKBN28K1IK. 
  37. ↑ "Egypt to produce up to 80 million Sinovac vaccine doses annually" (in en). 2021-04-08. https://arab.news/c44bc. 
  38. ↑ "WHO approves Sinovac COVID vaccine, the second Chinese-made dose listed". Reuters (Geneva). 2021-06-01. https://www.reuters.com/article/us-health-coronavirus-who-sinovac/who-approves-sinovac-covid-vaccine-the-second-chinese-made-dose-listed-idUSKCN2DD3V5. 
  39. ↑ "WHO recommendation Sinovac COVID-19 vaccine (Vero Cell [Inactivated) – CoronaVac"]. 1 May 2021. https://extranet.who.int/pqweb/vaccines/who-recommendation-sinovac-covid-19-vaccine-vero-cell-inactivated-coronavac. 
  40. ↑ "WHO validates Sinovac COVID-19 vaccine for emergency use and issues interim policy recommendations". World Health Organization (WHO) (Press release). Retrieved 1 June 2021.
  41. ↑ "Chinese drugmakers agree to supply more than half a billion vaccines to COVAX". 2021-07-12. https://www.reuters.com/world/gavi-signs-covid-19-vaccine-supply-deals-with-sinovac-sinopharm-covax-2021-07-12/. 

External links




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