Engineering:Diafiltration

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Short description: Dilution process
Diagram of a diafiltration device

Diafiltration is a dilution process that involves removal or separation of components (permeable molecules like salts, small proteins, solvents etc.,) of a solution based on their molecular size by using micro-molecule permeable filters in order to obtain pure solution.[1][2][3][4][5][6][7]

References

  1. ↑ Shao, Jiahui; Zydney, Andrew L. (2004). "Optimization of Ultrafiltration/Diafiltration Processes for Partially Bound Impurities". Biotechnology and Bioengineering 87 (3): 286–292. doi:10.1002/bit.20113. PMID 15281103. 
  2. ↑ Blatt, W.F.; Robinson, S.M.; Bixler, Harris J. (Oct 1968). "Membrane ultrafiltration: The diafiltration technique and its application to microsolute exchange and binding phenomena". Analytical Biochemistry 26 (1): 151–173. doi:10.1016/0003-2697(68)90039-0. PMID 5761168. 
  3. ↑ Schwartz, Larry. "Diafiltration: A Fast, Efficient Method for Desalting, or Buffer Exchange of Biological Samples". Literature Library. http://www.pall.com/main/laboratory/literature-library-details.page?id=50335. 
  4. ↑ "Protein Concentration and Diafiltration by Tangential Flow Filtration". Millipore. http://www.bio-link.org/home/sites/files/tff_technical_brief.pdf. 
  5. ↑ Sweeney, Scott F.; Woehrle, Gerd H.; Hutchison, James E. (2006). "Rapid Purification and Size Separation of Gold Nanoparticles via Diafiltration". Journal of the American Chemical Society 128 (10): 3190–3197. doi:10.1021/ja0558241. PMID 16522099. 
  6. ↑ Schwartz, Larry. "Diafiltration for Desalting or Buffer Exchange". BioProcess International. http://www.bioprocessintl.com/multimedia/archive/00077/0105ar06_77637a.pdf. 
  7. ↑ "Diafiltration (Buffer Exchange) Using Hollow Fiber Membranes instead of Dialysis Tubing - Automated Diafiltration". http://www.spectrumlabs.com/lit/hfdial.pdf. 

Further reading

  • Bowen, W. Richard; Mohammad, A. Wahab (Aug 1998). "Diafiltration by nanofiltration: Prediction and optimization". AIChE Journal 44 (8): 1799–1812. doi:10.1002/aic.690440811. 
  • Limayem, Imène; Charcosset, Catherine; Fessi, Hatem (2004). "Purification of nanoparticle suspensions by a concentration/diafiltration process". Separation and Purification Technology 38 (1): 1–9. doi:10.1016/j.seppur.2003.10.002. 
  • Sheth, Jignesh P. (2003). "Nanofiltration-based diafiltration process for solvent exchange in pharmaceutical manufacturing". Journal of Membrane Science 211 (2): 251–261. doi:10.1016/s0376-7388(02)00423-4. 

External links



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