Medicine:Anticipatory anxiety

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Future tripping, also referred to as anticipatory anxiety, describes a type of fear that occurs when an anticipated event in the future causes distress. These events can include both major occasions, such as a presentation, but depending on the individual could also happen before some minor event, like going out. It is not seen as a distinct type of anxiety but rather plays a part in many variations and can be found in numerous disorders and is strongly connected to panic attacks, often following them.[1]

Description

People who suffer from anticipatory anxiety can have a number of different symptoms. These can include being afraid of an event that will happen in the future and therefore presents an unpredictable threat to an individual, but can also include chest pains or hyperventilation. In some cases they can even make the person feel like they are dying or lose control.[2]

Anticipatory anxiety does not have one definitive cause but rather it plays a part in many anxiety-related disorders. It can arise through social anxiety disorder and be a consequence of bullying.[3] People who often suffer from panic attacks can grow to fear their onset and the repercussions that accompany them.[4][5][6] This is then an anticipatory anxiety, as something that is anticipated for the future causes anxiety in an individual. It can come out stronger in a situation where a stress-causing event cannot be predicted.[7][8]

Increased activity of the amygdala can lead to wrongfully processing threats, which could then be the reason for overly worrying about the future.[1] The anterior insula causes emotional responses to predicted events. If activated too strongly, this can lead to threat-uncertainty.[1]

Symptoms

The symptoms of future tripping can overlap with multiple different anxiety disorders. The main symptom is an extensive fear of an imagined event or situation that lays in the future, which the person thinks of as an "unpredictable threat".[1][5][8]

Other symptoms include:[2][5]

  • Palpitations
  • Shortness of breath
  • Nausea
  • Dizziness
  • Fear of dying, fainting, or losing control
  • Feeling worried, tense, stressed, or irritable
  • Feeling restless and unable to sit still
  • Having trouble being present in the moment and focusing on simple tasks

A person suffering from anticipatory anxiety may also experience fear of having a panic attack. Symptoms include hyperventilation, chest pains, and muscle spasms.[2][5]

Causes

There are no known general direct causes to anticipatory anxiety. Personal sensitivity and probability of anxiety occurring may be elevated by various factors.[9] A person's personality traits may put them at increased risk for anticipatory stress. People characterised as perfectionists have shown to be more vulnerable.[10] Excessive deliberation or overthinking may be a direct cause of the symptoms of anticipatory anxiety.[11] Some studies have shown correlation between stress level and one's perception of whether the stress inducing event is outside of one's control or if it can be affected or mitigated by them.[12]

Anticipatory anxiety has higher chances of occurring in the context of situations where the result of stress-inducing events is unpredictable.[8][7] Prior knowledge, anticipation, and understanding of potential consequences of the stressful event may significantly decrease the level of the anxiety.[7]

There are indications of smoking increasing anxiety among people with high anxiety sensitivity.[9][13]

Panic attacks

Anticipatory anxiety is a symptom of panic disorder, playing a role in its onset, maintenance and impairment. People who suffer from frequent spontaneous panic attacks might develop a persistent state of fear, or anxiety, relating to the anticipation of future panic attacks or their consequences.[4][5][6] The severity of this anxiety might be modified by cues assumed to trigger panic attacks, including bodily symptoms.[5] The freezing symptom, characteristic for panic disorder, is related to the lessened mobility associated with anticipatory anxiety.[14]

The Panic and Agoraphobia Scale scores on the basis of five elements, including the frequency and severity of anticipatory anxiety.[15] The severity of the anxiety serves as an indicator for avoidance behaviour in panic disorder and agoraphobia.[5][16]

People experiencing anticipated fear of epileptic seizures may also fear anticipated panic attacks. This can culminate into anticipatory seizure anxiety, seizure phobia, or epileptic panic disorder.[17]

Anxiety disorders

Anticipatory anxiety is a feature of social anxiety disorder. The Social Phobia Scale, a general self-report questionnaire used as measure for social anxiety disorder, contains the 'anticipatory anxiety related to being observed' as one of its main diagnostic items.[18] Peer victimisation, such as bullying, may increase levels of anticipatory anxiety and of developing social anxiety disorder.[3]

Avoidance behaviour associated with post-traumatic stress disorder increases anticipatory anxiety. This can be an indicator of post-traumatic anxiety disorders such as agoraphobia, social anxiety disorder, obsessive-compulsive disorder, or separation anxiety.[19]

Neuroanatomy

A wide network of brain areas are involved in anticipatory anxiety. The activity of the amygdala increases under conditions of uncertainty. The hyperactivity of the amygdala leads to increased vigilance and biased attention towards threat and deficient associative learning, which leads to higher expectancy of threat. These expectations cause a feedback loop where anxious individuals become increasingly more vigilant and attentive towards perceived threats. Increased attention influences the subjective value of potential future events. This value is assigned by the ventral striatum and orbitofrontal cortex, to which the amygdala is bidirectionally connected.[1]

Dopaminergic neurons in the midbrain generate prediction error signals, which reflect a mismatch between the predicted and the actual outcome. These error signals lead to more accurate future predictions for both rewarding and aversive stimuli. Hypothetical future events create an anticipatory emotional response from the anterior insula. Hyperactivity of the anterior insula can be observed in anticipation of negative events connected to absent decision-making or threat uncertainty. Already associated neuronal connections strengthen when behavioural patterns and anxious thoughts occur.[1]

The anterior midcingulate cortex is involved in the regulation of autonomic activity, direction of appropriate defensive responses, facilitation of response selection, and the increase of attentional resources. It projects to the motor cortex, amygdala, midbrain nuclei (including the periaqueductal grey), parietal regions and multiple medial and lateral prefrontal regions (including the dorsolateral prefrontal cortex). In clinical anxiety, the structure, function and connectivity of the anterior midcingulate cortex are altered.[1]

Treatment

Future tripping, another name for anticipatory anxiety, is a form of anxiety and therefore can be treated by a psychologist who can provide strategies to cope in a healthy manner.[4]

A regular practice of meditation can help overcome the want to control and apprehend the future, as the practice includes being aware of the present moment. This technique reduces the persistence of anxious thoughts, limiting the impact.[20][21]

Eating healthy food and exercising regularly have been shown to have a positive effect. Exercise releases stress from the body and can help distract from anxious thoughts.[20]

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Grupe, Dan W.; Nitschke, Jack B. (July 2013). "Uncertainty and anticipation in anxiety: an integrated neurobiological and psychological perspective" (in en). Nature Reviews Neuroscience 14 (7): 488–501. doi:10.1038/nrn3524. ISSN 1471-0048. PMID 23783199. 
  2. ↑ 2.0 2.1 2.2 "Anticipatory Anxiety: Signs, Symptoms, & Treatment" (in en-US). https://www.choosingtherapy.com/anticipatory-anxiety/. 
  3. ↑ 3.0 3.1 Pontillo, Maria; Tata, Maria Cristina; Averna, Roberto; Demaria, Francesco; Gargiullo, Prisca; Guerrera, Silvia; Pucciarini, Maria Laura; Santonastaso, Ornella et al. (June 2019). "Peer Victimization and Onset of Social Anxiety Disorder in Children and Adolescents" (in en). Brain Sciences 9 (6): 132. doi:10.3390/brainsci9060132. PMID 31174384. 
  4. ↑ 4.0 4.1 4.2 "DSM-5.pdf". https://drive.google.com/file/d/10r_oUv_fZXQ4jUVXQC-4UnMdaneR3TD5/view?usp=embed_facebook. 
  5. ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 Helbig-Lang, Sylvia; Lang, Thomas; Petermann, Franz; Hoyer, Jürgen (October 2012). "Anticipatory Anxiety as a Function of Panic Attacks and Panic-Related Self-Efficacy: An Ambulatory Assessment Study in Panic Disorder" (in en). Behavioural and Cognitive Psychotherapy 40 (5): 590–604. doi:10.1017/S1352465812000057. ISSN 1469-1833. PMID 22373714. https://www.cambridge.org/core/journals/behavioural-and-cognitive-psychotherapy/article/abs/anticipatory-anxiety-as-a-function-of-panic-attacks-and-panicrelated-selfefficacy-an-ambulatory-assessment-study-in-panic-disorder/F74B866DB57404E82BAB423D9F48689F. 
  6. ↑ 6.0 6.1 Locke, Amy B.; Kirst, Nell; Shultz, Cameron G. (2015-05-01). "Diagnosis and management of generalized anxiety disorder and panic disorder in adults". American Family Physician 91 (9): 617–624. ISSN 1532-0650. PMID 25955736. https://pubmed.ncbi.nlm.nih.gov/25955736/. 
  7. ↑ 7.0 7.1 7.2 Claar, Robyn Lewis; Walker, Lynn S.; Barnard, John A. (January 2002). "Children's Knowledge, Anticipatory Anxiety, Procedural Distress, and Recall of Esophagogastroduodenoscopy" (in en-US). Journal of Pediatric Gastroenterology and Nutrition 34 (1): 68–72. doi:10.1097/00005176-200201000-00016. ISSN 0277-2116. PMID 11753168. https://journals.lww.com/jpgn/Fulltext/2002/01000/Children_s_Knowledge,_Anticipatory_Anxiety,.00016.aspx. 
  8. ↑ 8.0 8.1 8.2 Grillon, Christian; Lissek, Shmuel; Rabin, Stephanie; McDowell, Dana; Dvir, Sharone; Pine, Daniel S. (2008-07-01). "Increased Anxiety During Anticipation of Unpredictable But Not Predictable Aversive Stimuli as a Psychophysiologic Marker of Panic Disorder". American Journal of Psychiatry 165 (7): 898–904. doi:10.1176/appi.ajp.2007.07101581. ISSN 0002-953X. PMID 18347001. 
  9. ↑ 9.0 9.1 McLeish, Alison C.; Zvolensky, Michael J.; Bucossi, Meggan M. (2007-01-01). "Interaction between smoking rate and anxiety sensitivity: Relation to anticipatory anxiety and panic-relevant avoidance among daily smokers" (in en). Journal of Anxiety Disorders 21 (6): 849–859. doi:10.1016/j.janxdis.2006.11.003. ISSN 0887-6185. PMID 17166696. https://www.sciencedirect.com/science/article/abs/pii/S0887618506001721. 
  10. ↑ Abdollahi, Abbas (2019-10-02). "The Association of Rumination and Perfectionism to Social Anxiety". Psychiatry 82 (4): 345–353. doi:10.1080/00332747.2019.1608783. ISSN 0033-2747. PMID 31112491. https://doi.org/10.1080/00332747.2019.1608783. 
  11. ↑ Hunter, Lindsay E.; Meer, Elana A.; Gillan, Claire M.; Hsu, Ming; Daw, Nathaniel D. (2019-01-17). "Excessive deliberation in social anxiety" (in en). bioRxiv: 522433. doi:10.1101/522433. https://www.biorxiv.org/content/10.1101/522433v1. 
  12. ↑ Li, Ho Cheung William; Chung, Oi Kwan Joyce (2009). "The Relationship Between Children's Locus of Control and Their Anticipatory Anxiety" (in en). Public Health Nursing 26 (2): 153–160. doi:10.1111/j.1525-1446.2009.00766.x. ISSN 1525-1446. PMID 19261154. https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1525-1446.2009.00766.x. 
  13. ↑ McLeish, Alison C.; Zvolensky, Michael J.; Ben, Kevin S. Del; Burke, Randy S. (2009-01-01). "Anxiety Sensitivity as a Moderator of the Association between Smoking Rate and Panic-Relevant Symptoms among a Community Sample of Middle-aged Adult Daily Smokers". American Journal on Addictions 18 (1): 93–99. doi:10.1080/10550490802408985. ISSN 1055-0496. PMID 19219671. https://www.tandfonline.com/doi/abs/10.1080/10550490802408985. 
  14. ↑ Lopes, Fabiana L.; Azevedo, Tatiana M.; Imbiriba, Luiz A.; Freire, Rafael C.; Valença, Alexandre M.; Caldirola, Daniela; Perna, Giampaolo; Volchan, Eliane et al. (2009). "Freezing reaction in panic disorder patients associated with anticipatory anxiety" (in en). Depression and Anxiety 26 (10): 917–921. doi:10.1002/da.20593. ISSN 1520-6394. PMID 19582830. https://onlinelibrary.wiley.com/doi/abs/10.1002/da.20593. 
  15. ↑ Bandelow, B. (June 1995). "Assessing the efficacy of treatments for panic disorder and agoraphobia. II. The Panic and Agoraphobia Scale" (in en-US). International Clinical Psychopharmacology 10 (2): 73–82. doi:10.1097/00004850-199506000-00003. ISSN 0268-1315. PMID 7673659. https://journals.lww.com/intclinpsychopharm/Abstract/1995/06000/Assessing_the_efficacy_of_treatments_for_panic.3.aspx. 
  16. ↑ Lohr, Jeffrey M.; Lilienfeld, Scott O.; Rosen, Gerald M. (2012-10-01). "Anxiety and its treatment: Promoting science-based practice" (in en). Journal of Anxiety Disorders 26 (7): 719–727. doi:10.1016/j.janxdis.2012.06.007. ISSN 0887-6185. PMID 22858898. https://www.sciencedirect.com/science/article/abs/pii/S0887618512000783. 
  17. ↑ Hingray, Coraline; McGonigal, Aileen; Kotwas, Iliana; Micoulaud-Franchi, Jean-Arthur (2019-04-29). "The Relationship Between Epilepsy and Anxiety Disorders". Current Psychiatry Reports 21 (6): 40. doi:10.1007/s11920-019-1029-9. ISSN 1535-1645. PMID 31037466. https://pubmed.ncbi.nlm.nih.gov/31037466/. 
  18. ↑ Herbert, James D.; Brandsma, Lynn L.; Fischer, Laura (2014-01-01). "Assessment of Social Anxiety and its Clinical Expressions" (in en). Social Anxiety: 45–94. doi:10.1016/B978-0-12-394427-6.00003-0. ISBN 9780123944276. https://www.sciencedirect.com/science/article/pii/B9780123944276000030. 
  19. ↑ Auxéméry, Yann (May 2018). "Post-traumatic psychiatric disorders: PTSD is not the only diagnosis". Presse Medicale (Paris, France: 1983) 47 (5): 423–430. doi:10.1016/j.lpm.2017.12.006. ISSN 2213-0276. PMID 29580906. https://pubmed.ncbi.nlm.nih.gov/29580906/. 
  20. ↑ 20.0 20.1 "How meditation can help anxiety" (in en). 2015-09-14. https://neuroscience.stanford.edu/news/how-meditation-can-help-anxiety. 
  21. ↑ Corliss, Julie (2014-01-08). "Mindfulness meditation may ease anxiety, mental stress" (in en). https://www.health.harvard.edu/blog/mindfulness-meditation-may-ease-anxiety-mental-stress-201401086967. 



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