Medicine:Factor VIII (medication)

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Short description: Pharmaceutical drug
Factor VIII
Fviii 2R7E.png
A depiction of factor VIII
Clinical data
Trade namesAafact, Kovaltry, others[1]
Other namesoctocog alfa
AHFS/Drugs.comMonograph
License data
Routes of
administration		Intravenous (IV)
ATC code
Legal status
Legal status
Identifiers
ChemSpider
  • none

Factor VIII is a medication used to treat and prevent bleeding in people with hemophilia A and other causes of low factor VIII.[6][7] Certain preparations may also be used in those with von Willebrand's disease.[7] It is given by slow injection into a vein.[6]

Side effects include skin flushing, shortness of breath, fever, and red blood cell breakdown.[6][7] Allergic reactions including anaphylaxis may occur.[7] It is unclear if use during pregnancy is safe for the fetus.[8] A purified factor VIII concentrate is made from human blood plasma.[7] A recombinant version is also available.[6] People may develop antibodies to factor VIII such that this medication becomes less effective.[8]

Factor VIII was first identified in the 1940s and became available as a medication in the 1960s.[9][10] Recombinant factor VIII was first made in 1984 and approved for medical use in the United States in 1992.[11][12] It is on the World Health Organization's List of Essential Medicines.[13]

Available forms

Factor VIII is delivered by intravenous infusion.[14]

History

This transfer of a plasma byproduct into the blood stream of a hemophiliac often led to the transmission of diseases such as HIV and hepatitis before purification methods were improved. In the early 1990s, pharmaceutical companies began to produce recombinant synthesized factor products, which now prevent nearly all forms of disease transmission during replacement therapy.[citation needed]

Society and culture

Economics

The cost of Factor VIII and similar clotting factors has been described as "highly expensive".[14] The cost of the clotting factors is 80% of all medical costs for people with hemophilia.[15] They are so expensive that gene therapy for haemophilia might be less expensive, especially for people with severe hemophilia.[15]

See also

References

  1. ↑ "Coagulation Factor VIII, Human". https://www.drugs.com/international/coagulation-factor-viii-human.html. 
  2. ↑ "Prescription medicines: registration of new chemical entities in Australia, 2017". 21 June 2022. https://www.tga.gov.au/resources/publication/publications/prescription-medicines-registration-new-chemical-entities-australia-2017. 
  3. ↑ "Prescription medicines: registration of new chemical entities in Australia, 2016". 21 June 2022. https://www.tga.gov.au/prescription-medicines-registration-new-chemical-entities-australia-2016. 
  4. ↑ "Prescription medicines: registration of new chemical entities in Australia, 2014". 21 June 2022. https://www.tga.gov.au/resources/resource/guidance/prescription-medicines-registration-new-chemical-entities-australia-2014. 
  5. ↑ "Search Page - Drug and Health Product Register". 23 October 2014. https://hpr-rps.hres.ca/reg-content/regulatory-decision-summary-detail.php?lang=en&linkID=RDS00364. 
  6. ↑ 6.0 6.1 6.2 6.3 WHO Model Formulary 2008. World Health Organization. 2009. pp. 259–60. ISBN 9789241547659. 
  7. ↑ 7.0 7.1 7.2 7.3 7.4 British National Formulary : BNF 69. British Medical Association. 2015. p. 171. ISBN 978-0857111562. 
  8. ↑ 8.0 8.1 "Alphanate – Summary of Product Characteristics (SPC) – (eMC)". https://www.medicines.org.uk/emc/medicine/21167. 
  9. ↑ "Chapter 5". Queen Victoria's Gene: Haemophilia and the Royal Family. The History Press. 2011. ISBN 978-0752471969. https://books.google.com/books?id=tKwTDQAAQBAJ&pg=PT61. 
  10. ↑ "In vivo characteristics of rDNA Factor VIII: The impact for the future in hemophilia care". Biotechnology in blood transfusion: Proceedings of the Twelfth Annual Symposium on Blood Transfusion, Groningen 1987, organized by the Red Cross Blood Bank Groningen-Drenthe. Springer Science & Business Media. 2012. p. 224. doi:10.1007/978-1-4613-1761-6_19. ISBN 978-1461317616. https://books.google.com/books?id=z1IlBAAAQBAJ&pg=PA224. 
  11. ↑ "Clotting factors VIII and IX". Recombinant Protein Drugs. Birkhäuser. 2012. p. 79. ISBN 978-3034883467. https://books.google.com/books?id=cSX3BwAAQBAJ&pg=PA79. 
  12. ↑ "Chapter 25 - Coagulation Factor Preparations". Blood Banking and Transfusion Medicine: Basic Principles & Practice. Elsevier Health Sciences. 2006. p. 353. doi:10.1016/B978-0-443-06981-9.50030-2. ISBN 0443069816. https://books.google.com/books?id=3QwXx_enKbcC&pg=PT374. 
  13. ↑ World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. 2019. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO. 
  14. ↑ 14.0 14.1 "Gene Therapy for Hemophilia". Hematology/Oncology Clinics of North America 31 (5): 853–868. October 2017. doi:10.1016/j.hoc.2017.06.011. PMID 28895852. 
  15. ↑ 15.0 15.1 "Gene therapy in hemophilia A: a cost-effectiveness analysis". Blood Advances 2 (14): 1792–1798. July 2018. doi:10.1182/bloodadvances.2018021345. PMID 30042145. 

External links



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