Medicine:Glassy cell carcinoma of the cervix
| Glassy cell carcinoma of the cervix | |
|---|---|
| Other names | Glassy cell carcinoma |
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| Micrograph of a glassy cell carcinoma of the cervix. H&E stain. | |
Glassy cell carcinoma of the cervix, also glassy cell carcinoma, is a rare aggressive malignant tumour of the uterine cervix.[1] The tumour gets its name from its microscopic appearance; its cytoplasm has a glass-like appearance.
Signs and symptoms
The signs and symptoms are similar to other cervical cancers and may include post-coital bleeding and/or pain during intercourse (dyspareunia). Early lesions may be completely asymptomatic.[citation needed]
Cause
Diagnosis
The diagnosis is based on tissue examination, e.g. biopsy.[citation needed]
Under the microscope, glassy cell carcinoma tumours are composed of cells with a glass-like cytoplasm, typically associated with an inflammatory infiltrate abundant in eosinophils and very mitotically active. PAS staining highlights the plasma membrane.[2]
Treatment
The treatment is dependent on the stage. Advanced tumours are treated with surgery (radical hysterectomy and bilateral salpingo-opherectomy), radiation therapy and chemotherapy.[2]
See also
Additional images
Low mag.
High mag.
References
- ↑ Nasu, K.; Takai, N.; Narahara, H. (Jun 2009). "Multimodal treatment for glassy cell carcinoma of the uterine cervix.". Journal of Obstetrics and Gynaecology Research 35 (3): 584–7. doi:10.1111/j.1447-0756.2008.00968.x. PMID 19527406.
- ↑ 2.0 2.1 Deshpande, AH.; Kotwal, MN.; Bobhate, SK. (2004). "Glassy cell carcinoma of the uterine cervix a rare histology. Report of three cases with a review of the literature.". Indian J Cancer 41 (2): 92–5. doi:10.4103/0019-509X.12353. PMID 15318016. http://www.indianjcancer.com/text.asp?2004/41/2/92/12353.
Further reading
- Greer, Benjamin E.; Koh, Wui-Jin; Abu-Rustum, Nadeem; Bookman, Michael A.; Bristow, Robert E.; Campos, Susana M.; Cho, Kathleen R.; Copeland, Larry et al. (1 May 2009). "Uterine Neoplasms" (in en). Journal of the National Comprehensive Cancer Network 7 (5): 498–531. doi:10.6004/jnccn.2009.0035. ISSN 1540-1405. PMID 19460278. http://www.jnccn.org/content/7/5/498.long. Retrieved 19 July 2017.
External links
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