Medicine:Lupus headache

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Short description: Disorder in patients with systemic lupus erythematosus

Lupus headache is a proposed, specific headache disorder in patients with systemic lupus erythematosus (SLE).[1][2] Research shows that headache is a symptom commonly described by SLE patients —57% in one meta-analysis, ranging in different studies from 33% to 78%;[3] of which migraine 31.7% and tension-type headache 23.5%. The existence of a special lupus headache is contested, although few high-quality studies are available to form definitive conclusions.[4][5]

Definition

Lupus headache is an important item in the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI), a scoring system often used in lupus research.[6] The SLEDAI describes lupus headache as a "severe, persistent headache; may be migrainous, but must be nonresponsive to narcotic analgesia".[4] A score of 8 is given to this item (items are given a relative weight of 1, 2, 4 or 8).[citation needed]

The 1999 American College of Rheumatology case definitions of neuropsychiatric syndromes in SLE do not define lupus headache, but rather propose several headache disorders loosely based on the International Headache Society (IHS) classification.[citation needed]

In the IHS scheme, headache due to lupus would be classified as "Headache attributed to other non-infectious inflammatory disease" (7.3.3). This label requires evidence of a disease flare accompanying the headache, and resolution of the headache with immunosuppressant treatment. However, a meta-analysis found no correlation between headaches and disease activity.[5]

Criticism

Critics of this concept argue that there are no quality studies showing that headaches in patients with SLE differ from those in the general population. A detailed definition of the term lupus headache is lacking, since the terms "severe" and "persistent" are not quantified. Narcotic analgesics are not recommended for migraines or other common headache types. Other definitions from the IHS do not include responsiveness to treatments as a diagnostic criterion.[3] Migraine patients are typically adult women around age 40, a demographic group in which SLE is also more common.[7]

Mechanism

Some (but not all) studies have shown an association between (migraine) headaches in SLE and associated Raynaud's phenomenon and/or anti-cardiolipin antibodies.[8][9][10][11][12][13][14][15][excessive citations] Further studies are needed however to prove the underlying assumption that cerebral vasospasm causes migraines in lupus patients.

Diagnosis

Although specific complications of SLE may cause headache (such as cerebral venous sinus thrombosis or posterior reversible encephalopathy syndrome), it remains unclear whether specific investigations (such as lumbar puncture or magnetic resonance imaging, MRI) are needed in lupus patients presenting with headache. Although studies using MRI or single-photon emission computed tomography (SPECT) often find abnormalities,[16][17] the value of these findings remains unclear, and they have not been able to distinguish a special "lupus headache" from other headache types in people with lupus.[18][19]

Footnotes

  1. ↑ "Headache and systemic lupus erythematosus". Lupus 12 (12): 943–6. 2003. doi:10.1191/0961203303lu506oa. PMID 14714915. http://openurl.ingenta.com/content/nlm?genre=article&issn=0961-2033&volume=12&issue=12&spage=943&aulast=Cuadrado. 
  2. ↑ "Lupus Headache". http://www.relieve-migraine-headache.com/lupus-headache.html. 
  3. ↑ 3.0 3.1 "The ACR classification criteria for headache disorders in SLE fail to classify certain prevalent headache types". Cephalalgia 28 (3): 296–9. March 2008. doi:10.1111/j.1468-2982.2007.01510.x. PMID 18254898. 
  4. ↑ 4.0 4.1 "The validity of the inclusion of "lupus headache" in the Systemic Lupus Erythematosus Disease Activity Index". Arthritis Rheum. 56 (8): 2812–3. August 2007. doi:10.1002/art.22798. PMID 17665430. 
  5. ↑ 5.0 5.1 "A meta-analysis for headache in systemic lupus erythematosus: the evidence and the myth". Brain 127 (Pt 5): 1200–9. May 2004. doi:10.1093/brain/awh146. PMID 15047589. 
  6. ↑ "Lupus headaches in childhood-onset systemic lupus erythematosus: relationship to disease activity as measured by the systemic lupus erythematosus disease activity index (SLEDAI) and disease damage". Lupus 12 (8): 600–6. 2003. doi:10.1191/0961203303lu430oa. PMID 12945718. http://openurl.ingenta.com/content/nlm?genre=article&issn=0961-2033&volume=12&issue=8&spage=600&aulast=Brunner. 
  7. ↑ Omdal R (2002). "Some controversies of neuropsychiatric systemic lupus erythematosus". Scand. J. Rheumatol. 31 (4): 192–7. doi:10.1080/030097402320318369. PMID 12369649. 
  8. ↑ "Headache, Raynaud's syndrome and serotonin receptor agonists in systemic lupus erythematosus". Lupus 15 (10): 671–4. 2006. doi:10.1177/0961203306069997. PMID 17120594. http://lup.sagepub.com/cgi/pmidlookup?view=long&pmid=17120594. 
  9. ↑ "Headache and systemic lupus erythematosus: prevalence and associated conditions" (in pt). Arq Neuropsiquiatr 65 (4B): 1196–9. December 2007. doi:10.1590/S0004-282X2007000700020. PMID 18345429. 
  10. ↑ "[Migraine in SLE: role of antiphospholipid antibodies and Raynaud's phenomenon"] (in it). Reumatismo 58 (1): 50–8. 2006. doi:10.4081/reumatismo.2006.50. PMID 16639488. http://www.reumatismo.org/admin/filesArticoli/58-1-50.pdf. 
  11. ↑ "Prevalence and classification of headache in patients with systemic lupus erythematosus". Clin. Rheumatol. 25 (6): 850–3. November 2006. doi:10.1007/s10067-005-0186-x. PMID 16437362. 
  12. ↑ "Prevalence and factors associated with headache in patients with systemic lupus erythematosus". Cephalalgia 24 (12): 1031–44. December 2004. doi:10.1111/j.1468-2982.2004.00822.x. PMID 15566417. 
  13. ↑ "Clinical implications of migraine in systemic lupus erythematosus: relation to cumulative organ damage". Cephalalgia 24 (12): 1024–30. December 2004. doi:10.1111/j.1468-2982.2004.00785.x. PMID 15566416. 
  14. ↑ "Headaches in patients with systemic lupus erythematosus: a comparative study". Lupus 13 (7): 501–5. 2004. doi:10.1191/0961203304lu1050oa. PMID 15352420. http://openurl.ingenta.com/content/nlm?genre=article&issn=0961-2033&volume=13&issue=7&spage=501&aulast=Whitelaw. 
  15. ↑ "Headache in systemic lupus erythematosus: a controlled study". Br. J. Rheumatol. 37 (3): 300–3. March 1998. doi:10.1093/rheumatology/37.3.300. PMID 9566671. 
  16. ↑ "Migraine during systemic lupus erythematosus: findings from brain single photon emission computed tomography". J. Rheumatol. 33 (11): 2184–91. November 2006. PMID 17086605. http://www.jrheum.com/subscribers/06/11/2184.html. Retrieved 2009-02-02. 
  17. ↑ "Brain single-photon emission tomography with 99mTc-HMPAO in neuropsychiatric systemic lupus erythematosus: relations with EEG and MRI findings and clinical manifestations". Eur J Nucl Med 22 (1): 17–24. January 1995. doi:10.1007/BF00997243. PMID 7698150. 
  18. ↑ "Single photon emission computed tomography and magnetic resonance imaging evaluation in SLE patients with and without neuropsychiatric involvement". Rheumatology (Oxford) 47 (3): 319–23. March 2008. doi:10.1093/rheumatology/kem354. PMID 18218648. 
  19. ↑ "The use of single photon emission computerized tomography in neuropsychiatric SLE: a pilot study". J. Rheumatol. 22 (7): 1247–53. July 1995. PMID 7562753. 



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