Medicine:Rasmussen aneurysm
Rasmussen aneurysm is a distinctive variant of pseudoaneurysm of a branch of the pulmonary artery, predominantly found adjacent to or within a lung cavity, both often arising as a complication of pulmonary tuberculosis.[1][2] The condition was originally described by Fritz Valdemar Rasmussen in 1868.[3] It is a relatively uncommon complication associated with cavitary tuberculosis of the lung, with its prevalence observed in approximately 5–8% of cases based on autopsy findings.[4]
It is caused by the progressive thinning of the pulmonary artery wall. This weakening process is characterized by the replacement of both the tunica externa and tunica media with granulation tissue, which subsequently undergoes transformation into fibrin. This tissue remodeling is a consequence of the healing response in the associated lung cavity. The dilation of the pulmonary artery in close proximity to or involvement within the lung cavity leads to the formation of a pseudoaneurysm.[2][4] As is typical with any aneurysm, Rasmussen aneurysm carries the inherent risk of rupture, which may result in life-threatening massive hemoptysis, characterized by the coughing of blood. Such events are associated with a mortality rate exceeding 50%.[2][5]
Historically, Rasmussen aneurysms were widely regarded as a common etiology of hemoptysis, particularly in tuberculosis cases. However, with advancements in antibiotic therapy and improvements in medical knowledge, contemporary understanding has evolved. Current medical insight suggests that the majority of hemoptysis cases are more closely linked to bleeding originating from the systemic bronchial arteries within the lung, with pulmonary artery aneurysms accounting for less than 10% of cases.[6][7] This shift has led to a significant alteration in the approach taken by medical professionals in the diagnosis and management of hemoptysis within clinical practice.
It is worth noting that while Rasmussen aneurysm was initially associated exclusively with cavitary tuberculosis, the term is now utilized to encompass any anatomical aneurysm occurring in conjunction with various forms of destructive lung lesions.
References
- ↑ "Rasmussen aneurysm" (in en), Radiopaedia.org, 2010-05-27, doi:10.53347/rid-9839, http://radiopaedia.org/articles/9839, retrieved 2023-09-15
- ↑ 2.0 2.1 2.2 "Rasmussen Aneurysm". Radiology. Cardiothoracic Imaging 3 (3): e210026. June 2021. doi:10.1148/ryct.2021210026. PMID 34235447.
- ↑ Rasmussen, V. On hemoptysis, especially when fatal, in its anatomical and clinical aspects. (Translated from the Hospitals-Tidende, 11th year, nos. 9–13, Copenhagen, February and March, 1868, by Moore WD). Edinburgh Med J. 1868; 14: 385–401
- ↑ 4.0 4.1 "Rasmussen aneurysm: A rare but not gone complication of tuberculosis". International Journal of Infectious Diseases 69: 8–10. April 2018. doi:10.1016/j.ijid.2018.01.023. PMID 29410220.
- ↑ "Fatal haemoptysis caused by a ruptured Rasmussen's aneurysm". Thorax 66 (6): 553–554. June 2011. doi:10.1136/thx.2010.135616. PMID 20805157.
- ↑ "Aneurysms of the pulmonary arteries". Chest 94 (5): 1065–1075. November 1988. doi:10.1378/chest.94.5.1065. PMID 3053058.
- ↑ "Rasmussen's aneurysm: A forgotten scourge". Respiratory Medicine Case Reports 16: 74–76. 2015-08-12. doi:10.1016/j.rmcr.2015.08.003. PMID 26744661.
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