Organization:ITM2A
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Integral membrane protein 2A is a protein that in humans is encoded by the ITM2A gene.[1][2][3][4]
Function
The protein encoded by this gene is involved in osteo- and chondrogenic cellular differentiation (the cells which are responsible for the development of bone and cartilage respectively).[2]
ITM2A is also involved in activation of T-cells in the immune system[5] and in myocyte differentiation.[6]
References
- ↑ "Genomic organization and chromosomal localization of the Itm2a gene". Mamm Genome 10 (1): 54–6. Mar 1999. doi:10.1007/s003359900942. PMID 9892734.
- ↑ 2.0 2.1 "Isolation of markers for chondro-osteogenic differentiation using cDNA library subtraction. Molecular cloning and characterization of a gene belonging to a novel multigene family of integral membrane proteins". J Biol Chem 271 (32): 19475–82. Sep 1996. doi:10.1074/jbc.271.32.19475. PMID 8702637.
- ↑ "Entrez Gene: ITM2A integral membrane protein 2A". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9452.
- ↑ "Identification of genes expressed in human CD34+ hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 95 (14): 8175–80. July 1998. doi:10.1073/pnas.95.14.8175. PMID 9653160. Bibcode: 1998PNAS...95.8175M.
- ↑ "Itm2a Is Induced during Thymocyte Selection and T Cell Activation and Causes Downregulation of Cd8 When Overexpressed in Cd4+Cd8+ Double Positive Thymocytes". J. Exp. Med. 190 (2): 217–28. July 1999. doi:10.1084/jem.190.2.217. PMID 10432285.
- ↑ "Constitutive overexpression of the integral membrane protein Itm2A enhances myogenic differentiation of C2C12 cells". Cell Biol. Int. 28 (3): 199–207. 2004. doi:10.1016/j.cellbi.2003.11.019. PMID 14984746.
Further reading
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "Analysis of differential gene expression by display of 3' end restriction fragments of cDNAs". Proc. Natl. Acad. Sci. U.S.A. 93 (2): 659–63. 1996. doi:10.1073/pnas.93.2.659. PMID 8570611. Bibcode: 1996PNAS...93..659P.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "Identification of genes expressed in human CD34+ hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 95 (14): 8175–80. 1998. doi:10.1073/pnas.95.14.8175. PMID 9653160. Bibcode: 1998PNAS...95.8175M.
- "Itm2a Is Induced during Thymocyte Selection and T Cell Activation and Causes Downregulation of Cd8 When Overexpressed in Cd4+Cd8+ Double Positive Thymocytes". J. Exp. Med. 190 (2): 217–28. 1999. doi:10.1084/jem.190.2.217. PMID 10432285.
- "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. 2001. doi:10.1101/gr.140200. PMID 11042152.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. 2003. doi:10.1101/gr.1293003. PMID 12975309.
- "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "The DNA sequence of the human X chromosome". Nature 434 (7031): 325–37. 2005. doi:10.1038/nature03440. PMID 15772651. Bibcode: 2005Natur.434..325R.
External links
- ITM2A+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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