Organization:Royan Institute

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Royan Institute
پژوهشگاه رویان
TypeResearch Institute
Established1991
PresidentProf. Abdolhossein Shahverdi
Location
Tehran and Isfahan
,
Iran
WebsiteOfficial website

Royan Institute (Persian: پژوهشگاه رویان‎) is an Iranian clinical research and educational institute dedicated to biomedical, translational and clinical research, stem cell research, and infertility treatment. It is a public non-profitable organization affiliated to Academic Center for Education, Culture, and Research.[1] It was established in 1991 by the late Dr. Saeid Kazemi Ashtiani[2][1] as a research institute for Reproductive Biomedicine and infertility treatments. In 1998 this institute was approved by the Ministry of Health as Cell-Based Research Center with over 46 scientific members and 186 lab technicians. Iran ranks second in the list of countries where stem cell research is popular.[3]

history

Stem cell research in Iran began on a high note after the leader Ali Khamenei Emphasized on this type of research in 2002. Unlike the United States , which has discussed using human embryos in stem cell research, Iran has not encountered such obstacles. Iran has been able to make great progress in the 14 years of its research activity in this field.[3][4]

Research institutes

Royan consists of three research institutes, each focused on different fields of research:

  • Royan Institute for Stem Cell Biology and Technology (RI-SCBT)[1]
  • Royan Institute for Reproductive Biomedicine (RI-RB)[2]
  • Royan Institute for Developmental Biotechnology (RI-AB)[3]

The institute has had close collaborations with other leading Iranian research centers such as Institute of Biochemistry and Biophysics[5] (IBB), NRCGEB, and the Hematology-Oncology and Stem Cell Transplantation Research Center at Shariati Hospital in Tehran.

Royan publishes the Cell Journal with an impact factor of 3.128 (2022).[6]


Royan Institute for Stem Cell Biology and Technology

Royan Institute for Stem Cell Biology and Technology (RI-SCBT)[7] first, as the "Department of Stem Cells," was established in 2002 to advance research on biology and technology of embryonic stem cells, induced pluripotent stem cells, germ line stem cells, adult stem cells, cancer stem cells, and cord blood stem cells.

The institute provides a comprehensive and coordinated "bench to bedside" approach to regenerative medicine, including a greater understanding of the fundamental biology of stem cells, developmental biology, tissue engineering programs, the development of translational research of stem cell therapeutics, and administration of new cell therapies approach that can restore tissue function to patients.

The RI-SCBT comprises four departments including the Department of stem cells and developmental biology,[8] the Department of cell engineering,[9] the Department of regenerative medicine,[10] and the Department of brain and cognitive sciences.[11]

Iran has some of the most liberal laws on stem cell research in the world. The institute founded a Department of Stem Cells in 2002 to establish human embryonic stem cell lines and Induced Pluripotent Stem Cell (iPSC), and to study differentiation into different kinds of cells including cardiomyocytes, beta cells, and neural cells. Researchers claimed a live birth of a cloned sheep in 2006, inviting foreign observers to verify the claim.[12]

Royan Institute for Reproductive Biomedicine

Royan Institute for Reproductive Biomedicine (RI-RB),[13] founded in 1991, consists of six departments and one clinic actively working on different aspects of infertility and the development of new methods for infertility treatment.

It aims to improve the population's health through infertility treatments and research different aspects of infertility and its treatment to increase the success rate alongside improving embryo health.

Royan Institute for Developmental Biotechnology

Developmental Biotechnology (RI-DB)[14] was initially established in 2004 as a research sub-institute that is located in Isfahan Province. The endeavors of RI-DB have made Royan Institute the pioneer of animal cloning in Iran and the Middle East. Coming up with the first cloned sheep in the Middle East in 2006 placed Iran among the few countries having this technology.[15] Making use of this technology in producing transgenic animals has led to bringing the goats into being in Isfahan and Tehran (2009) with the ability to secrete human coagulation factor 9 and human Tissue Plasminogen Activator (hTPA) in their milk.

The vision of RI-DB is to achieve high standards in biotechnology research and to make biotechnology a premier precision tool for future health development.

RI-DB includes the Animal Biotechnology department, three research groups, and four laboratories.

Chronological overview

  • 1993: The first IVF birth in Tehran[16]
  • 1995: The second ICSI birth in Iran[17]
  • 1996: Iran's second success in open testicular biopsy to treat severe male infertility[18]
  • 1996: The first frozen embryo birth in Iran[19]
  • 1999: The first ICSI birth by frozen sperm of a gonadectomized man[20]
  • 1999: The first celebration of the 1000th birth through assisted conception treatment in Iran[21]
  • 2003: The first human embryonic Stem Cell line establishment in Iran and the region[22]
  • 2003: Establishment of Stem Cells research department[23]
  • 2004: The first PGD child born in Iran[24]
  • 2004: The first time use of adult stem cells in the treatment of MI during CABG in Iran[25]
  • 2004: Production of insulin-producing cells from human embryonic stem cells.[1]
  • 2004: Culture of Human Limbal Stem Cells on Chorionic Membrane and use them for corneal injuries[26]
  • 2005: Establishment of the first Private Cord Blood Bank in Iran (Royan Stem Cell Technology Co.)[27]
  • 2006: The first IVM-IVF sheep born in Iran[28]
  • 2006: Iran's first cloned sheep, named Royana.[29]
  • 2006: The first nuclear transferred, in vitro fertilized sheep born[30]
  • 2007: Culture and transplantation of fibroblasts[31]
  • 2008: Establishment of mouse and human induced pluripotent stem cells (iPS)[32]
  • 2008: Transplantation of melanocytes for the patient with vitiligo[33]
  • 2009: The first cloned goat was born in Iran.[34]
  • 2010: The first transgenic goats born in Irans[35]
  • 2011: The first calves born from vitrified in vitro developed embryos in Iran[36]
  • 2011: Establishment of cell therapy pre-hospital[37]
  • 2011: Establishmentof Stem Cell Bank[38]
  • 2012: The first healthy childbirth after Molecular PGD for beta-thalassemia in Iran[39]
  • 2013: Birth of eight cloned goats through the simplified method of SCNT in Iran[40]
  • 2015: Birth of a cloned Isfahan mouflon to a surrogate domestic sheep.[41]
  • 2016: The first knock-in mice produced with CRISPR technology in Iran.[42]
  • 2017: The first transgenic zebrafish disease models in Iran.[43]
  • 2017: The first cryopreserved human ovarian tissue auto-transplantation in cancer patients.[44]
  • 2018: Establishment of the Faculty of Basic Sciences and Medical Technology in Royan Institute[45]
  • 2018: Establishment of the Advanced Therapy Medicinal Product Technology Development Center (ATMP)[46]
  • 2019: Obtaining the license to produce Kimia-cell in GMP conditions in Royan – ATMP Center from Iran FDA[47]
  • 2020: Producing the transgene Covid mouse for pre-clinical studies of Covid-19 vaccines[48]
  • 2020: Receiving the international ISO certificate; ISO 9001:2015 for Laboratory Animal Science Core Facility
  • 2021: Implementing the phase I clinical trial for Natural Killer cell therapy for pediatric glioblastoma[49]
  • 2022: Commercialization of human gamete and embryo freeze-thaw media[50]

Prominent achievements

  • Report of three new mutation of cystic fibrosis
  • Best paper selection in MEFS congress 2004
  • Second place of Razi medical science award 2003
  • Best young researcher in Razi medical science award 2004
  • Report of human embryonic stem cells’ proteomics for the first time in the world
  • Registration of one human embryonic stem cell line in International Society of Stem Cell Research
  • Establishment of 6 human embryonic stem cell lines
  • Establishment of 8 mouse embryonic stem cell lines which three of them can be donated to the centers or researchers for one time
  • Introduction of late director of Royan Institute as Iran's everlasting legend in 2005
  • Best poster award in Stem Cell congress, India, 2005
  • Selection as “prominent research center” in Razi medical sciences award
  • Best researcher in Razi medical sciences award 2006
  • Best medical journal (Cell Journal (yakhteh) ) in Razi medical sciences award 2006
  • Best research achievement prize in Razi medical sciences award
  • Best research achievement prize in Kharazmi young researcher award 2006
  • Best research prize in second international reproduction student award, Yazd, Iran, 2007
  • Report of Mesenchymal stem cells’ new surface markers to the world
  • Publication of 626 papers in local and international journals
  • Performance of 341 research project and follow of 225 undergoing projects
  • Presentation of 997 papers in national and international congresses
  • Publication of two journals: Cell Journal(Yakhteh) and IJFS (Iranian Journal of Fertility and Sterility), Indexed in ISI
  • Editorial board of four internationals
  • six chapters of international textbooks in stem cell fields
  • Publication of 21 books
  • Performance of more than 56 inter-center and multi-center research nationally or internationally
  • Use of adult stem cells in corneal injuries and myocardial infarction on human
  • Transplantation of stem cells to the animal model of diseases in hepatic cirrhosis, spinal cord injuries, bone defects, cartilage damages and diabetes
  • Several research achievements in preimplantation diagnosis and screening
  • Producing iPS cell line, Royan H7
  • Registration of T338A, K536X, Y122H genes in CBAVD (Congenital Bilateral Absence of Vas Deferens) patients, 2007

See also

Notes

  1. ↑ 1.0 1.1 1.2 Miremadi, Tahereh (2013). "Chapter 7: Biotechnology in Iran: A study of the structure and functions of the technology innovation system". in Soofi, Abdol S.; Ghazinoory, Sepehr. Science and innovations in Iran: development, progress, and challenges. New York: Palgrave Macmillan. pp. 139–158. ISBN 9781137030092. 
  2. ↑ "Memorial - Royan Institute". http://www.royaninstitute.org/cmsen/index.php?option=com_content&task=view&id=62&Itemid=106&phpMyAdmin=d320eb7f7212d3b0351b3507d45b4afc. 
  3. ↑ 3.0 3.1 "Countries Where Stem Cell Research Is Most Popular". https://www.worldatlas.com/articles/countries-where-stem-cell-research-is-most-popular.html. 
  4. ↑ "Iran in the forefront when it comes to stem cell research". https://edition-cnn-com.translate.goog/2006/WORLD/meast/11/16/raman.iranstemcell/index.html?_x_tr_sl=fa&_x_tr_tl=en&_x_tr_hl=en-US&_x_tr_pto=wapp. 
  5. ↑ https://ibb.ut.ac.ir/
  6. ↑ https://celljournal.org/
  7. ↑ https://royanstemcell.ir/
  8. ↑ https://royanstemcell.ir//
  9. ↑ https://royanstemcell.ir///
  10. ↑ https://royanstemcell.ir//
  11. ↑ https://royanstemcell.ir//
  12. ↑ Aneesh Raman CNN (2006-11-17). "Iran in the forefront when it comes to stem cell research - CNN.com". Edition.cnn.com. http://edition.cnn.com/2006/WORLD/meast/11/16/raman.iranstemcell/index.html. 
  13. ↑ "Reproductive Biomedicine - Royan Institute". http://www.royaninstitute.org/cmsen/index.php?option=com_content&task=section&id=6&Itemid=41. 
  14. ↑ https://en.royan-edu.ir/
  15. ↑ https://www.theguardian.com//
  16. ↑ https://www.sciencedirect.com/
  17. ↑ https://www.royan.org/
  18. ↑ https://www.sciencedirect.com/
  19. ↑ https://www.sid.ir/FileServer/JE/107320080208
  20. ↑ https://connect.isti.ir/media/associations/Introduction/royan.pdf
  21. ↑ https://connect.isti.ir/media/associations/Introduction/royan.pdf
  22. ↑ https://www.ncbi.nlm.nih.gov/
  23. ↑ https://royanstemcell.ir/
  24. ↑ https://www.sciencedirect.com/
  25. ↑ https://www.frontiersin.org/
  26. ↑ https://www.sid.ir/FileServer/JE/82320190402
  27. ↑ https://www.rsct.ir/
  28. ↑ https://www.jstor.org/
  29. ↑ Sheikhi, Marjohn (30 September 2015). "Birth anniversary of Royana; Iran's 1st cloned sheep" (in en). Mehr News Agency. https://en.mehrnews.com/news/110629/Birth-anniversary-of-Royana-Iran-s-1st-cloned-sheep. 
  30. ↑ https://www.sid.ir/FileServer/JE/82320083905
  31. ↑ https://www.ncbi.nlm.nih.gov/
  32. ↑ https://stemcellres.biomedcentral.com/
  33. ↑ https://royanipd.com/
  34. ↑ https://www.nbcnews.com/
  35. ↑ http://www.payvand.com/news/13/apr/1198.html
  36. ↑ https://www.sid.ir/FileServer/JE/107320110407
  37. ↑ https://www.royan.org/
  38. ↑ https://parentsguidecordblood.org/
  39. ↑ https://www.sid.ir/fileserver/je/57006820130209
  40. ↑ https://connect.isti.ir/media/associations/Introduction/royan.pdf
  41. ↑ Dehghan, Saeed Kamali (5 August 2015). "Scientists in Iran clone endangered mouflon – born to domestic sheep". The Guardian. https://www.theguardian.com/science/2015/aug/05/iran-scientists-clone-endangered-mouflon-domestic-sheep. 
  42. ↑ https://www.sciencedirect.com/science/article/am/pii/S0303720718300881
  43. ↑ https://zfin.org/ZDB-LAB-191210-1
  44. ↑ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948080/
  45. ↑ https://www.royan.org/en/Page/17/Faculty-of-Basic-Sciences-and-Medical-Technology/
  46. ↑ https://www.royan.org/
  47. ↑ https://www.royanatmp.com/wp-content/uploads/2017/10/Regulations-on-Biological-products_March-2018.pdf
  48. ↑ https://onlinelibrary.wiley.com/doi/10.1111/and.13842
  49. ↑ https://clinicaltrials.gov/
  50. ↑ https://www.ijfs.ir/article_45880_e4188ad3309fbba12ec5adfb6e77d3d5.pdf

External links




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