Physics:Fidgetin-like 2
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Fidgetin-like 2 (FL2) is an enzyme which in humans is encoded by the gene FIGNL2. FL2 slows the rate at which skin cells migrate to wounds to heal them. If this enzyme is suppressed/absent, skin cells move faster, speeding the healing process.[1] FL2 is closely related to another protein called fidgetin (encoded by FIGN in humans), which severs microtubules.[1]
Delivery
Molecules of silencing RNA (siRNA) that bind to a gene's messenger RNA (mRNA) can inhibit the production of FL2, but siRNAs require protection from degradation in order to reach a wound site.[2]
In 2015, researchers disclosed the successful use of nanoparticles to ferry siRNA molecules to their intended targets, reducing healing times in mice with skin excisions or burns. The result was normal, well-orchestrated tissue, including hair follicles and supportive collagen network.[1][2]
References
- ↑ 1.0 1.1 1.2 "Fidgetin-Like 2: A Microtubule-Based Regulator of Wound Healing". The Journal of Investigative Dermatology 135 (9): 2309–2318. September 2015. doi:10.1038/jid.2015.94. PMID 25756798.
- ↑ 2.0 2.1 "Nanoparticles help wounds to heal 50 percent faster". Gizmag. March 30, 2015. http://www.gizmag.com/nanoparticles-wounds-heal-faster/36780.
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