Physics:Reactive carbonyl species
From HandWiki
Reactive carbonyl species (RCS) are molecules with highly reactive carbonyl groups, and often known for their damaging effects on proteins, nucleic acids, and lipids. They are often generated as metabolic products. Important RCSs include 3-deoxyglucosone, glyoxal, and methylglyoxal. RCSs react with amines and thiol groups leading to advanced glycation endproducts (AGEs). AGE's are indicators of diabetes.[1]
Reactive aldehyde species (RASP),[2] such as malondialdehyde and 4-hydroxynonenal, are a subset of RCS that are implicated in a variety of human diseases.[3]
See also
References
- ↑ Bellier, Justine; Nokin, Marie-Julie; Lardé, Eva; Karoyan, Philippe; Peulen, Olivier; Castronovo, Vincent; Bellahcène, Akeila (2019). "Methylglyoxal, a Potent Inducer of AGEs, Connects Between Diabetes and Cancer". Diabetes Research and Clinical Practice 148: 200–211. doi:10.1016/j.diabres.2019.01.002. PMID 30664892.
- ↑ Mandell, Kenneth J.; Clark, David; Chu, David S.; Foster, C. Stephen; Sheppard, John; Brady, Todd C. (2020). "Randomized Phase 2 Trial of Reproxalap, a Novel Reactive Aldehyde Species Inhibitor, in Patients with Noninfectious Anterior Uveitis: Model for Corticosteroid Replacement". Journal of Ocular Pharmacology and Therapeutics 36 (10): 732–739. doi:10.1089/jop.2020.0056. ISSN 1557-7732. PMID 32955967.
- ↑ Ayala, Antonio; Muñoz, Mario F.; Argüelles, Sandro (2014). "Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal". Oxidative Medicine and Cellular Longevity 2014: 360438. doi:10.1155/2014/360438. ISSN 1942-0994. PMID 24999379.
 |  |
