Software:Eyewire
| Eyewire | |
|---|---|
 | |
| Developer(s) | Sebastian Seung of Princeton University (formerly Massachusetts Institute of Technology) |
| Director(s) | Amy Sterling |
| Platform(s) | Webbrowser (WebGL) |
| Release | December 10, 2012 |
| Genre(s) | Puzzle, Citizen Science |
Eyewire is a citizen science game from Sebastian Seung's Lab at Princeton University. It is a human-based computation game that uses players to map retinal neurons. Eyewire launched on December 10, 2012. The game utilizes data generated by the Max Planck Institute for Medical Research.[1]
Eyewire gameplay is used for neuroscience research by enabling the reconstruction of morphological neuron data, which helps researchers model information-processing circuits.[2][3]
Gameplay
The player is given a cube with a partially reconstructed neuron branch stretching through it. The player completes the reconstruction by coloring a 2D image with a 3D image generated simultaneously. Reconstructions are compared across players as each cube is submitted, yielding a consensus reconstruction that is later checked by experienced players.
Goal
Eyewire is used to advance the use of artificial intelligence in neuronal reconstruction.[4] The project is also used in research determining how mammals see directional motion.[5][6]
Methods
The activity of each neuron in a 350 × 300 × 60 μm3 portion of a retina was determined by two-photon microscopy.[7] Using serial block-face scanning electron microscopy, the same volume was stained to bring out the contrast of the plasma membranes, sliced into layers by a microtome, and imaged using an electron microscope.
A neuron is selected by the researchers. The program chooses a cubic volume associated with that neuron for the player, along with an artificial intelligence's best guess for tracing the neuron through the two-dimensional images.[8]
Publications
- Kim, Jinseop S; Greene, Matthew J; Zlateski, Aleksandar; Lee, Kisuk; Richardson, Mark; Turaga, Srinivas C; Purcaro, Michael; Balkam, Matthew et al. (2014). "Space–time wiring specificity supports direction selectivity in the retina". Nature 509 (7500): 331–336. doi:10.1038/nature13240. PMID 24805243. Bibcode: 2014Natur.509..331..
- Greene, Matthew J; Kim, Jinseop S; Seung, H Sebastian (2016). "Analogous Convergence of Sustained and Transient Inputs in Parallel on and off Pathways for Retinal Motion Computation". Cell Reports 14 (8): 1892–900. doi:10.1016/j.celrep.2016.02.001. PMID 26904938.
- Tinati, Ramine; Luczak-Roesch, Markus; Simperl, Elena; Hall, Wendy (2017). "An investigation of player motivations in Eyewire, a gamified citizen science project". Computers in Human Behavior 73: 527–40. doi:10.1016/j.chb.2016.12.074.
Accomplishments
- Eyewire neurons featured at 2014 TED Conference Virtual Reality Exhibit.[9][10]
- Eyewire neurons featured at US Science and Engineering Expo in Washington, DC.[11]
- Eyewire won the National Science Foundation's 2013 International Visualization Challenge in the Games and Apps Category.[12]
- An Eyewire image by Alex Norton won MIT's 2014 Koch Image Gallery Competition.[13]
- Eyewire named one of Discover Magazine's Top 100 Science Stories of 2013.[14]
- Eyewire named top citizen science project of 2013 by SciStarter.[15]
- Eyewire won Biovision's World Life Sciences Forum Catalyzer Prize on March 26, 2013.[16]
- Eyewire named to top 10 citizen science projects of 2013 by PLoS.[17]
Eyewire has been featured by Wired,[18] Nature's blog SpotOn,[19] Forbes ,[20] Scientific American,[21] and NPR.[22]
References
- ↑ "About << Eyewire". http://eyewire.org/about/.
- ↑ Kim, Jinseop S; Greene, Matthew J; Zlateski, Aleksandar; Lee, Kisuk; Richardson, Mark; Turaga, Srinivas C; Purcaro, Michael; Balkam, Matthew et al. (2014). "Space–time wiring specificity supports direction selectivity in the retina". Nature 509 (7500): 331–336. doi:10.1038/nature13240. PMID 24805243. Bibcode: 2014Natur.509..331..
- ↑ Tinati, Ramine; Luczak-Roesch, Markus; Simperl, Elena; Shadbolt, Nigel; Hall, Wendy (2015). "'/Command' and Conquer: Analysing Discussion in a Citizen Science Game". Proceedings of the ACM Web Science Conference on ZZZ - Web Sci '15. p. 26. doi:10.1145/2786451.2786455. ISBN 978-1-4503-3672-7. https://eprints.soton.ac.uk/377766/1/2015___WebScience___EyeWire__Quant_.pdf.
- ↑ "Neural networks: Theory and Applications". http://seunglab.org/courses/neuralnets15/.
- ↑ "Retina << Eyewire". http://eyewire.org/retina.
- ↑ "Eyewire". http://eyewire.org/.
- ↑ "Challenge << Eyewire". http://eyewire.org/challenge/.
- ↑ Sebastian Seung (March 18, 2012). "Very small sections of neuron". http://forum.eyewire.org/discussion/8/very-small-sections-of-neuron-#Item_11. "A few more words of explanation for the curious...you color neurons on Eyewire by guiding an artificial intelligence (AI). The AI was trained to color the branches of neurons."
- ↑ "At TED, Worldwide Telescope uses Oculus Rift to let attendees experience the universe - Next at Microsoft - Site Home - TechNet Blogs". http://blogs.technet.com/b/next/archive/2014/03/19/at-ted-worldwide-telescope-uses-oculus-rift-to-let-attendees-experience-the-universe.aspx#.U1AjneZdXKg.
- ↑ "Yes, that's Commander Chris Hadfield wearing the Oculus Rift. (And yes, the Internet just exploded.)". 26 March 2014. http://blog.ted.com/2014/03/25/yes-thats-commander-chris-hadfield-wearing-the-oculus-rift-and-yes-the-internet-just-exploded/.
- ↑ "USA Science & Engineering Festival - The Nation's Largest Science Festival". http://www.usasciencefestival.org/.
- ↑ "Science: 2013 International Science and Engineering Visualization Challenge Winners Announced". 5 February 2014. http://www.aaas.org/news/science-2013-international-science-and-engineering-visualization-challenge-winners-announced.
- ↑ "Koch2014winners: Cell Press". http://www.cell.com/pictureshow/koch2014winners.
- ↑ "Science For the People, By the People". http://discovermagazine.com/2014/jan-feb/76-science-for-the-people-by-the-people.
- ↑ "Top 13 Citizen Science Projects of 2013". 1 January 2014. http://scistarter.com/blog/2014/01/top-13-citizen-science-projects-2013/#sthash.Rz9YzHim.dpbs.
- ↑ "BIOVISION Catalyzer". http://www.biovision.org/focus2-catalyzer.html.
- ↑ "Top Citizen Science Projects of 2012 - CitizenSci". 31 December 2012. http://blogs.plos.org/citizensci/2012/12/31/top-citizen-science-projects-of-2012/.
- ↑ Stinson, Liz (2 August 2013). "A Videogame That Recruits Players to Map the Brain". Wired. https://www.wired.com/2013/08/a-video-game-that-lets-you-be-a-neuroscientist/. Retrieved 10 November 2019.
- ↑ SpotOn Editor (14 March 2013). "SpotOn NYC: Communication and the brain – A Game to Map the Brain". Nature. http://www.nature.com/spoton/2013/03/spoton-nyc-communication-and-the-brain-a-game-to-map-the-brain/.
- ↑ Frank, Aaron; with Vivek Wadhwa (19 August 2013). "70,000+ Have Played 'Eyewire' Game That Trains Computers to Map the Brain". Forbes. https://www.forbes.com/sites/singularity/2013/08/19/70000-have-played-eyewire-game-that-trains-computers-to-map-the-brain/. Retrieved 10 November 2019.
- ↑ "Update: EyeWire". Scientific American. 13 June 2014. http://www.scientificamerican.com/citizen-science/update-eyewire-mit/. Retrieved April 17, 2014.
- ↑ Palca, Joe (5 March 2013). "Wanna Play? Computer Gamers Help Push Frontier of Brain Research". Morning Edition (NPR). https://www.npr.org/2013/03/05/173435599/wanna-play-computer-gamers-help-push-frontier-of-brain-research.
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