Biology:HEAT repeat
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| HEAT repeat | |||||||||||
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 An example of an alpha solenoid structure composed of 15 HEAT repeats. The protein phosphatase 2A regulatory subunit is shown with the N-terminus in blue at bottom and the C-terminus in red at top. A single helix-turn-helix motif is shown in the center with the outer helix in pink, the inner helix in green, and the turn in white. From PDB: 2IAE.[1][2] | |||||||||||
| Identifiers | |||||||||||
| Symbol | HEAT | ||||||||||
| Pfam | PF02985 | ||||||||||
| InterPro | IPR000357 | ||||||||||
| PROSITE | PDOC50077 | ||||||||||
| SCOP2 | 1b3u / SCOPe / SUPFAM | ||||||||||
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A HEAT repeat is tandem repeat protein structural motif composed of two alpha helices linked by a short loop. HEAT repeats can form alpha solenoids, a type of solenoid protein domain found in a number of cytoplasmic proteins. The name "HEAT" is an acronym for four proteins in which this repeat structure is found: Huntingtin, elongation factor 3 (EF3), protein phosphatase 2A (PP2A), and the yeast kinase TOR1.[3] HEAT repeats form extended superhelical structures which are often involved in intracellular transport; they are structurally related to armadillo repeats. The nuclear transport protein importin beta contains 19 HEAT repeats.
References
- ↑ Cho, Uhn Soo; Xu, Wenqing (1 November 2006). "Crystal structure of a protein phosphatase 2A heterotrimeric holoenzyme". Nature 445 (7123): 53–57. doi:10.1038/nature05351. PMID 17086192.
- ↑ "The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs". Cell 96 (1): 99–110. January 1999. doi:10.1016/S0092-8674(00)80963-0. PMID 9989501.
- ↑ "HEAT repeats in the Huntington's disease protein". Nat. Genet. 11 (2): 115–6. October 1995. doi:10.1038/ng1095-115. PMID 7550332.
External links
- Eukaryotic Linear Motif resource motif class LIG_PIKK_1
- Eukaryotic Linear Motif resource motif class DOC_PIKK_1
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