Biology:Daf-1
From HandWiki
Short description: Protein-coding gene in the species Caenorhabditis elegans
| abnormal dauer formation protein 1 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Organism | |||||||
| Symbol | daf-1 | ||||||
| Entrez | 176829 | ||||||
| HomoloGene | 134382 | ||||||
| UniProt | P20792 | ||||||
| Other data | |||||||
| Chromosome | IV: 0.13 - 0.14 Mb | ||||||
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The DAF-1 gene encodes for a cell surface Enzyme-linked receptor of TGF-beta signaling pathway in the worm Caenorhabditis elegans.[1] DAF-1 is one of the type I receptor of TGF-beta pathway.[2] DAF-1 acts as a receptor protein serine/threonine kinase, is activated by type II receptor Daf-4 phosphorylation after the ligand Daf-7 binds to the receptor heterotetramer, and then phosphorylates Daf-8 or Daf-14, the SMAD proteins in C. elegans.[3]
References
- ↑ "daf-1, a C. elegans gene controlling dauer larva development, encodes a novel receptor protein kinase". Cell 61 (4): 635–45. May 1990. doi:10.1016/0092-8674(90)90475-t. PMID 2160853.
- ↑ "A DAF-1-binding protein BRA-1 is a negative regulator of DAF-7 TGF-beta signaling". Proceedings of the National Academy of Sciences of the United States of America 98 (11): 6284–8. May 2001. doi:10.1073/pnas.111409798. PMID 11353865. Bibcode: 2001PNAS...98.6284M.
- ↑ "Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans". Development 126 (2): 251–60. January 1999. doi:10.1242/dev.126.2.251. PMID 9847239.
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