Biology:ALOX15B
 Generic protein structure example |
Arachidonate 15-lipoxygenase type II is an enzyme that in humans is encoded by the ALOX15B gene.[1][2] ALOX15B, also known as 15-lipoxygenase-2 (15-LO-2 or 15-LOX-2), is distinguished from its related oxygenase, ALOX15 or 15-lipoxygenase-1.
Function
This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. 15-LOX-2 has 38-39% amino acid sequence identity to human 15-LOX-1 and 12-lipoxygenase and 44% amino acid sequence identity to human 5-lipoxygenase.[1] 15-LOX-2 converts arachidonic acid almost exclusively to the S stereoisomer of 15-Hydroperoxyicosatetraenoic acid which is commonly reduced to the S stereoisomer 15-Hydroxyeicosatetraenoic acid by ubiquitous cellular peroxidases; it metabolizes linoleic acid less effectively, converting this fatty acid to the S stereoisomer of 13-hydroperoxyoctadecadienoic acid which is likewise rapidly reduced to the S stereoisomer of 13-Hydroxyoctadecadienoic acid.[1] The ALOX15B gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described.[2]
See also
- Arachidonate 15-lipoxygenase
- 15-hydroxyicosatetraenoic acid
- ALOX15
References
- ↑ 1.0 1.1 1.2 "Discovery of a second 15S-lipoxygenase in humans". Proceedings of the National Academy of Sciences of the United States of America 94 (12): 6148–52. Jun 1997. doi:10.1073/pnas.94.12.6148. PMID 9177185. Bibcode: 1997PNAS...94.6148B.
- ↑ 2.0 2.1 "Entrez Gene: ALOX15B arachidonate 15-lipoxygenase, type B". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=247.
External links
- Human ALOX15B genome location and ALOX15B gene details page in the UCSC Genome Browser.
Further reading
- "Expression of cloned human reticulocyte 15-lipoxygenase and immunological evidence that 15-lipoxygenases of different cell types are related". The Journal of Biological Chemistry 265 (9): 5113–20. Mar 1990. doi:10.1016/S0021-9258(19)34092-X. PMID 2318885.
- "Differential characteristics of human 15-lipoxygenase isozymes and a novel splice variant of 15S-lipoxygenase". European Journal of Biochemistry 266 (1): 83–93. Nov 1999. doi:10.1046/j.1432-1327.1999.00818.x. PMID 10542053.
- "A gene cluster encoding human epidermis-type lipoxygenases at chromosome 17p13.1: cloning, physical mapping, and expression". Genomics 73 (3): 323–30. May 2001. doi:10.1006/geno.2001.6519. PMID 11350124.
- "Evidence that arachidonate 15-lipoxygenase 2 is a negative cell cycle regulator in normal prostate epithelial cells". The Journal of Biological Chemistry 277 (18): 16189–201. May 2002. doi:10.1074/jbc.M111936200. PMID 11839751.
- "Reduced 15S-lipoxygenase-2 expression in esophageal cancer specimens and cells and upregulation in vitro by the cyclooxygenase-2 inhibitor, NS398". Neoplasia 5 (2): 121–7. 2003. doi:10.1016/s1476-5586(03)80003-9. PMID 12659684.
- "Subcellular localization and tumor-suppressive functions of 15-lipoxygenase 2 (15-LOX2) and its splice variants". The Journal of Biological Chemistry 278 (27): 25091–100. Jul 2003. doi:10.1074/jbc.M301920200. PMID 12704195.
- "Evidence that Sp1 positively and Sp3 negatively regulate and androgen does not directly regulate functional tumor suppressor 15-lipoxygenase 2 (15-LOX2) gene expression in normal human prostate epithelial cells". Oncogene 23 (41): 6942–53. Sep 2004. doi:10.1038/sj.onc.1207913. PMID 15247906.
- "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Research 14 (9): 1711–8. Sep 2004. doi:10.1101/gr.2435604. PMID 15342556.
- "Angiotensin II increases the expression of lectin-like oxidized low-density lipoprotein receptor-1 in human vascular smooth muscle cells via a lipoxygenase-dependent pathway". American Journal of Hypertension 18 (3): 299–307. Mar 2005. doi:10.1016/j.amjhyper.2004.09.008. PMID 15797645.
- "Inverse relationship between 15-lipoxygenase-2 and PPAR-gamma gene expression in normal epithelia compared with tumor epithelia". Neoplasia 7 (3): 280–93. Mar 2005. doi:10.1593/neo.04457. PMID 15799828.
- "Reduction of isoforms of 15-lipoxygenase (15-LOX)-1 and 15-LOX-2 in human breast cancer". Prostaglandins, Leukotrienes, and Essential Fatty Acids 74 (4): 235–45. Apr 2006. doi:10.1016/j.plefa.2006.01.009. PMID 16556493.
- "15-Lipoxygenase-2 gene regulation by its product 15-(S)-hydroxyeicosatetraenoic acid through a negative feedback mechanism that involves peroxisome proliferator-activated receptor gamma". Oncogene 25 (44): 6015–25. Sep 2006. doi:10.1038/sj.onc.1209617. PMID 16682954.
- "Novel mutations in ALOX12B in patients with autosomal recessive congenital ichthyosis and evidence for genetic heterogeneity on chromosome 17p13". The Journal of Investigative Dermatology 127 (4): 829–34. Apr 2007. doi:10.1038/sj.jid.5700640. PMID 17139268.
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