Medicine:Autism Diagnostic Observation Schedule

Autism Diagnostic Observation Schedule
Medical diagnostics
Purpose	for assessment of autism

The Autism Diagnostic Observation Schedule (ADOS) is an instrument for diagnosing and assessing autism. The protocol consists of a series of structured and semi-structured tasks that involve social interaction between the examiner and the person under assessment. The examiner observes and identifies segments of the subject's behavior and assigns these to predetermined observational categories. Categorized observations are subsequently combined to produce quantitative scores for analysis. Research-determined cut-offs identify the potential diagnosis of classic autistic disorder or related autism spectrum disorders, allowing a standardized assessment of autistic symptoms. The Autism Diagnostic Interview-Revised (ADI-R), a companion instrument, is a structured interview conducted with the parents of the referred individual and covers the subject's full developmental history.

History

The Autism Diagnostic Observation Schedule was created by Catherine Lord, Ph.D., Michael Rutter, M.D., FRS, Pamela C. DiLavore, Ph.D., and Susan Risi, Ph.D. in 1989. It became commercially available in 2001 through WPS (Western Psychological Services).

Method

The ADOS consists of a series of structured and semi-structured tasks and generally takes from 30 to 60 minutes to administer. During this time the examiner provides a series of opportunities for the subject to show social and communication behaviors relevant to the diagnosis of autism.

Each subject is administered activities from just one of the four modules. The selection of an appropriate module is based on the developmental and language level of the referred individual. The only developmental level not served by the ADOS is that for adolescents and adults who are nonverbal. The ADOS should not be used for formal diagnosis with individuals who are blind, deaf, or otherwise seriously impaired by sensory or motor disorders, such as cerebral palsy or muscular dystrophy.

Modules

Module 1 is used with children who use little or no phrase speech. Subjects that do use phrase speech but do not speak fluently are administered Module 2. Since these modules both require the subject to move around the room, the ability to walk is generally taken as a minimum developmental requirement to use of the instrument as a whole. Module 3 is for younger subjects who are verbally fluent and Module 4 is used with adolescents and adults who are verbally fluent. Some examples of Modules 1 or 2 include response to name, social smile, and free or bubble play. Modules 3 or 4 can include reciprocal play and communication, exhibition of empathy or comments on others' emotions.

Revision

A revision, the Autism Diagnostic Observation Schedule, Second Edition (ADOS-2), was released by WPS in May 2012. It includes updated norms, improved algorithms for Modules 1 to 3 and a new Toddler Module that facilitates assessment in children ages 12 to 30 months.

Training

There are several organizations that offer training in the ADOS-2.

WPS offers an ADOS-2 Clinical Workshop for professionals unfamiliar with the ADOS-2. It provides attendees the opportunity to observe an instructor administering the ADOS-2 to a child with ASD. During the administration attendees practice scoring. The workshop focuses primarily on Modules 1 through 4, though attendees are given materials to study later in order to complete training in the Toddler Module.

The clinical workshop offered through WPS is a prerequisite to the more thorough research training offered by the ADOS-2 authors and their colleagues. Research training includes exercises to establish item coding accuracy to a specific criterion, and is designed to help individuals achieve the high cross-site interrater reliability that is required in published research. CADB also offers other training opportunities, such as one-day workshops focused solely on learning the Toddler Module (for researchers and clinicians who are already trained in Modules 1-4 of the ADOS or ADOS-2).

Diagnostic accuracy

The social communication difficulties which the ADOS and ADOS-2 seek to measure are not unique to ASD; there is a heightened risk of false positives in individuals with other psychological disorders. In particular, an increased level of false positives has been observed in adults suffering from psychosis; while case reports indicate that such false positives may also occur in cases of childhood-onset schizophrenia. There is evidence that adults with schizophrenia demonstrate an increased incidence of autistic features compared to the general population, resulting in higher ADOS scores. A 2016 study found that 21% of children with a diagnosis of ADHD (and without a concurrent diagnosis of ASD) scored in the autism spectrum range on the ADOS total score.

A 2018 Cochrane systematic review included 12 studies of ADOS diagnostic accuracy in pre-school children (Modules 1 and 2). The summary sensitivity was 0.94 (95% CI 0.89 to 0.97), with sensitivity in individual studies ranging from 0.76 to 0.98. The summary specificity was 0.80 (95% CI 0.68 to 0.88), with specificity in individual studies ranging from 0.20 to 1.00. The studies were evaluated for bias using the QUADAS-2 framework; of the 12 included studies, 8 were evaluated as having a high risk of bias, while for the remaining four there was insufficient information available for the risk of bias to be properly evaluated. The authors could not identify any studies for the ADOS-2; the scope of the review was limited to preschool age children (mean age under 6 years), which excluded studies of Modules 3 and 4 from the meta-analysis. One included study examined the additive sensitivity and specificity of the ADOS used in combination with the ADI-R; that study found an 11% improvement in specificity (compared to ADOS alone) at the cost of a 14% reduction in sensitivity; however, due to overlapping confidence intervals, that result could not be considered statistically significant.

Further reading

• "Autism diagnostic observation schedule: a standardized observation of communicative and social behavior". Journal of Autism and Developmental Disorders 19 (2): 185–212. June 1989. doi:10.1007/BF02211841. PMID 2745388. 
• "A replication of the Autism Diagnostic Observation Schedule (ADOS) revised algorithms". Journal of the American Academy of Child and Adolescent Psychiatry 47 (6): 642–51. June 2008. doi:10.1097/CHI.0b013e31816bffb7. PMID 18434924. 
• "The Autism Diagnostic Observation Schedule-toddler module: a new module of a standardized diagnostic measure for autism spectrum disorders". Journal of Autism and Developmental Disorders 39 (9): 1305–20. September 2009. doi:10.1007/s10803-009-0746-z. PMID 19415479. 

External links

• Autism Resource - Glossary of Terms
• FAQs on the ADOS
• The ADOS test from a Parents Point of View