Medicine:Coronary reflex
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Coronary reflex is the change of coronary diameter in response to chemical, neurological or mechanical stimulation of the coronary arteries. The coronary reflexes are stimulated differently from the rest of the vascular system.[citation needed]
Causes of coronary constriction
Chemical
- N-nitro L-arginine
- indomethacin
- glibenclamide
- tetraethylammonium chloride
- caffeine
Other
- Cold
Causes of coronary dilation
Cocaine abuse frequently can cause a coronary spasm, resulting in a spontaneous myocardial infarction.[citation needed]
Chemical
- Versed (Midazolam): a coronary dilator. In midazolam's presence, dilation was unaffected by N-nitro L-arginine, indomethacin and glibenclamide.
- Tetraethylammonium chloride, an inhibitor of the BKCa K+ channel (a high conductance Ca2+-sensitive K+ channel), dose dependently attenuated the vasodilating effect of midazolam [1]
- Estrogen has been shown to abolish abnormal cold-induced coronary constriction.[2]
References
- ↑ O.L. Woodman; G.J. Dusting (1991). "N-nitro L-arginine causes coronary vasoconstriction and inhibits endothelium-dependent vasodilatation in anaesthetized greyhounds". Br. J. Pharmacol. 103 (2): 1407–1410. doi:10.1111/j.1476-5381.1991.tb09802.x. PMID 1909199.
- ↑ Steven E. Reis, MD; Richard Holubkov; Kathleen A. Zell, BSN; AJ. Conrad Smith, MD; Howard A. Cohen, MD; Marc D. Feldman, MD; Roger S. Blumenthal, MD (1998). "Estrogen Acutely Abolishes Abnormal Cold-Induced Coronary Constriction in Men*". Chest 114 (6): 1556–1561. doi:10.1378/chest.114.6.1556. PMID 9872188.
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