Biology:HORMA domain
From HandWiki
| HORMA domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 crystal structure of mad1-mad2 reveals a conserved mad2 binding motif in mad1 and cdc20. | |||||||||
| Identifiers | |||||||||
| Symbol | HORMA | ||||||||
| Pfam | PF02301 | ||||||||
| InterPro | IPR003511 | ||||||||
| SCOP2 | 1duj / SCOPe / SUPFAM | ||||||||
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In molecular biology, the HORMA domain (named after the Hop1p, Rev7p and MAD2 proteins) is a protein domain that has been suggested to recognise chromatin states resulting from DNA adducts, double stranded breaks or non-attachment to the spindle and act as an adaptor that recruits other proteins. Hop1 is a meiosis-specific protein, Rev7 is required for DNA damage induced mutagenesis, and MAD2 is a spindle checkpoint protein which prevents progression of the cell cycle upon detection of a defect in mitotic spindle integrity.[1][2]
Examples
Humans proteins containing this domain include:
References
- ↑ "The Schizosaccharomyces pombe spindle checkpoint protein mad2p blocks anaphase and genetically interacts with the anaphase-promoting complex.". Proc Natl Acad Sci U S A 94 (15): 7965–70. 1997. doi:10.1073/pnas.94.15.7965. PMID 9223296. Bibcode: 1997PNAS...94.7965H.
- ↑ "The HORMA domain: a common structural denominator in mitotic checkpoints, chromosome synapsis and DNA repair.". Trends Biochem Sci 23 (8): 284–6. 1998. doi:10.1016/S0968-0004(98)01257-2. PMID 9757827.
External links
- Eukaryotic Linear Motif resource motif class LIG_MAD2
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