Biology:CSNK1E
 Generic protein structure example |
Casein kinase I isoform epsilon is an enzyme that in humans is encoded by the CSNK1E gene.[1][2]
Function
The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate proteins of the Period family of circadian rhythm proteins. A homolog of this mammalian protein can be found in Drosophila melanogaster. Known as doubletime, this protein also plays a role in the phosphorylation of proteins involved in circadian rhythms. Two transcript variants encoding the same protein have been found for this gene.[3]
Interactions
CSNK1E has been shown to interact with PER1[4] and AXIN1.[5]
Inhibitors
- Selective
- Non-selective
- PF-670462 (also inhibits CK1-δ)
See also
References
- ↑ "Isolation and characterization of human casein kinase I epsilon (CKI), a novel member of the CKI gene family". The Journal of Biological Chemistry 270 (25): 14875–83. Jun 1995. doi:10.1074/jbc.270.25.14875. PMID 7797465.
- ↑ "Casein kinase iepsilon in the wnt pathway: regulation of beta-catenin function". Proceedings of the National Academy of Sciences of the United States of America 96 (22): 12548–52. Oct 1999. doi:10.1073/pnas.96.22.12548. PMID 10535959.
- ↑ "Entrez Gene: CSNK1E casein kinase 1, epsilon". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1454.
- ↑ "Nuclear entry of the circadian regulator mPER1 is controlled by mammalian casein kinase I epsilon". Molecular and Cellular Biology 20 (13): 4888–99. Jul 2000. doi:10.1128/MCB.20.13.4888-4899.2000. PMID 10848614.
- ↑ "Casein kinase I and casein kinase II differentially regulate axin function in Wnt and JNK pathways". The Journal of Biological Chemistry 277 (20): 17706–12. May 2002. doi:10.1074/jbc.M111982200. PMID 11884395.
External links
- Human CSNK1E genome location and CSNK1E gene details page in the UCSC Genome Browser.
- PDBe-KB provides an overview of all the structure information available in the PDB for Human Casein kinase I isoform epsilon (CSNK1E)
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