Biology:Adiponectin receptor 1
From HandWiki
 Generic protein structure example |
Adiponectin receptor 1 (AdipoR1) is a protein which in humans is encoded by the ADIPOR1 gene.[1] It is a member of the progestin and adipoQ receptor (PAQR) family, and is also known as PAQR1.[2]
Structure
Similar to G protein-coupled receptors (GPCRs), AdipoR1 also possesses 7 transmembrane domains. However, AdipoR1 is orientated oppositely to GPCRs in the membrane (i.e., cytoplasmic N-terminus, extracellular C-terminus) and does not associate with G proteins.[1]
Function
The adiponectin receptors, AdipoR1 and AdipoR2, serve as receptors for globular and full-length adiponectin and mediate increased AMPK and PPAR-α ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin.[1][3] In 2016, the University of Tokyo announced it was launching an investigation into anonymously made claims of fabricated and falsified data on the identification of AdipoR1 and AdipoR2.[4]
Ligands
Agonists
Peptide
- Adiponectin
- ADP-355[5]
- ADP-399[5]
Non-peptide
Antagonists
Peptide
- ADP-400[5]
See also
- Adiponectin receptor
- Adiponectin receptor 2
References
- ↑ 1.0 1.1 1.2 "Cloning of adiponectin receptors that mediate antidiabetic metabolic effects". Nature 423 (6941): 762–9. June 2003. doi:10.1038/nature01705. PMID 12802337. Bibcode: 2003Natur.423..762Y.
- ↑ "PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif". Journal of Molecular Evolution 61 (3): 372–80. September 2005. doi:10.1007/s00239-004-0375-2. PMID 16044242. Bibcode: 2005JMolE..61..372T.
- ↑ "Entrez Gene: ADIPOR1 adiponectin receptor 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51094.
- ↑ University of Tokyo to investigate data manipulation charges against six prominent research groups ScienceInsider, Dennis Normile, Sep 20, 2016
- ↑ 5.0 5.1 5.2 "Development of second generation peptides modulating cellular adiponectin receptor responses". Frontiers in Chemistry 2: 93. 2014. doi:10.3389/fchem.2014.00093. PMID 25368867. Bibcode: 2014FrCh....2...93O.
- ↑ "A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity". Nature 503 (7477): 493–9. November 2013. doi:10.1038/nature12656. PMID 24172895. Bibcode: 2013Natur.503..493O.
- ↑ 7.0 7.1 7.2 7.3 "Identification of adiponectin receptor agonist utilizing a fluorescence polarization based high throughput assay". PLOS ONE 8 (5): e63354. 2013. doi:10.1371/journal.pone.0063354. PMID 23691032. Bibcode: 2013PLoSO...863354S.
External links
- Human ADIPOR1 genome location and ADIPOR1 gene details page in the UCSC Genome Browser.
Further reading
- "Polymorphisms in adiponectin receptor genes ADIPOR1 and ADIPOR2 and insulin resistance". Obesity Reviews 8 (5): 419–23. September 2007. doi:10.1111/j.1467-789X.2007.00348.x. PMID 17716299.
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. January 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. October 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Research 10 (5): 703–13. May 2000. doi:10.1101/gr.10.5.703. PMID 10810093.
- "Cloning of adiponectin receptors that mediate antidiabetic metabolic effects". Nature 423 (6941): 762–9. June 2003. doi:10.1038/nature01705. PMID 12802337. Bibcode: 2003Natur.423..762Y.
- "Expression of adiponectin receptors in pancreatic beta cells". Biochemical and Biophysical Research Communications 312 (4): 1118–22. December 2003. doi:10.1016/j.bbrc.2003.11.042. PMID 14651988.
- "Adiponectin receptors gene expression and insulin sensitivity in non-diabetic Mexican Americans with or without a family history of Type 2 diabetes". Diabetologia 47 (5): 816–20. May 2004. doi:10.1007/s00125-004-1359-x. PMID 15105989.
- "Adiponectin receptor 1 gene (ADIPOR1) as a candidate for type 2 diabetes and insulin resistance". Diabetes 53 (8): 2132–6. August 2004. doi:10.2337/diabetes.53.8.2132. PMID 15277397.
- "Expression of adiponectin receptor mRNA in human skeletal muscle cells is related to in vivo parameters of glucose and lipid metabolism". Diabetes 53 (9): 2195–201. September 2004. doi:10.2337/diabetes.53.9.2195. PMID 15331527.
- "Adiponectin and its receptors are expressed in bone-forming cells". Bone 35 (4): 842–9. October 2004. doi:10.1016/j.bone.2004.06.008. PMID 15454091.
- "The effects of exercise and adipose tissue lipolysis on plasma adiponectin concentration and adiponectin receptor expression in human skeletal muscle". European Journal of Endocrinology 152 (3): 427–36. March 2005. doi:10.1530/eje.1.01872. PMID 15757860.
- "Absence of an association between the polymorphisms in the genes encoding adiponectin receptors and type 2 diabetes". Diabetologia 48 (7): 1307–14. July 2005. doi:10.1007/s00125-005-1806-3. PMID 15918014.
- "Genetic variation in adiponectin receptor 1 and adiponectin receptor 2 is associated with type 2 diabetes in the Old Order Amish". Diabetes 54 (7): 2245–50. July 2005. doi:10.2337/diabetes.54.7.2245. PMID 15983228.
- "Regulation of adiponectin receptor 1 in human hepatocytes by agonists of nuclear receptors". Biochemical and Biophysical Research Communications 334 (3): 924–9. September 2005. doi:10.1016/j.bbrc.2005.06.187. PMID 16023994.
- "Expression of AdipoR1 in vivo in skeletal muscle is independently associated with measures of truncal obesity in middle-aged caucasian men". Diabetes Care 28 (8): 2058–60. August 2005. doi:10.2337/diacare.28.8.2058. PMID 16043761.
- "PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif". Journal of Molecular Evolution 61 (3): 372–80. September 2005. doi:10.1007/s00239-004-0375-2. PMID 16044242. Bibcode: 2005JMolE..61..372T.
- "Adiponectin and its receptors in patients with chronic hepatitis C". Journal of Hepatology 43 (6): 929–36. December 2005. doi:10.1016/j.jhep.2005.05.030. PMID 16139921.
 |
