Biology:Progestin and adipoQ receptor

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Short description: Group of receptors

The progestin and adipoQ receptor (PAQR) family is a group of receptors related to but distinct from the G protein-coupled receptor family, which have the similar seven transmembrane structure, but the N-terminal is located on the inner side of the cell.[1] It includes at least 11 receptors (PAQR1–PAQR11), including the adiponectin (adipoQ) receptors (AdipoRs), the membrane progesterone receptors (mPRs), and others.[1]

In 2016, the University of Tokyo announced that it would launch an investigation into claims of fabrication of AdipoRs identification data, as accused by an anonymous person/group called Ordinary researchers.[2]

List of PAQRs

AdipoRs

  • PAQR1 (AdipoR1)
  • PAQR2 (AdipoR2)

mPRs

  • PAQR5 (mPRγ)
  • PAQR6 (mPRδ)
  • PAQR7 (mPRα)
  • PAQR8 (mPRβ)
  • PAQR9 (mPRϵ)

Others

  • PAQR3
  • PAQR4
  • PAQR10
  • PAQR11

References

  1. ↑ 1.0 1.1 Tang, Y. Tom; Hu, Tianhua; Arterburn, Matthew; Boyle, Bryan; Bright, Jessica M.; Emtage, Peter C.; Funk, Walter D. (2005). "PAQR Proteins: A Novel Membrane Receptor Family Defined by an Ancient7-Transmembrane Pass Motif". Journal of Molecular Evolution 61 (3): 372–380. doi:10.1007/s00239-004-0375-2. ISSN 0022-2844. PMID 16044242. 
  2. ↑ University of Tokyo to investigate data manipulation charges against six prominent research groups ScienceInsider, Dennis Normile, Sep 20, 2016




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