Chemistry:Drug liking

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Drug liking is a measure of the pleasurable (hedonic) experience when a person consumes drugs.[1] It is commonly used to study the misuse liability of drugs.[2][3][4] Drug liking is often measured using unipolar and bipolar visual analogue scales (VAS), such as the Drug Liking VAS, the High VAS, the Take Drug Again (TDA) VAS, and the Overall Drug Liking (ODL) VAS.[2][4] There is a dissociation of drug liking from drug wanting (unconscious attribution of incentive salience).[1][5] Drugs that increase scores on drug-liking measures include amphetamines, cocaine, methylphenidate, MDMA, opioids, benzodiazepines, Z-drugs, barbiturates, alcohol, nicotine, and caffeine (limitedly), among others.[3][6][4][7][8][9][10][11][12]

References

  1. 1.0 1.1 "Implicit measures of "wanting" and "liking" in humans". Neurosci Biobehav Rev 57: 350–64. October 2015. doi:10.1016/j.neubiorev.2015.09.015. PMID 26432503. https://biblio.ugent.be/publication/6956559. 
  2. 2.0 2.1 "Improving the Clinical Pharmacologic Assessment of Abuse Potential: Part 2: Optimizing the Design of Human Abuse Potential Studies". J Clin Psychopharmacol 38 (2): 113–118. April 2018. doi:10.1097/JCP.0000000000000838. PMID 29360651. 
  3. 3.0 3.1 "Assessment of abuse liability of stimulant drugs in humans: a methodological survey". Drug Alcohol Depend 28 (1): 3–48. June 1991. doi:10.1016/0376-8716(91)90052-z. PMID 1679387. 
  4. 4.0 4.1 4.2 "Core outcome measures for opioid abuse liability laboratory assessment studies in humans: IMMPACT recommendations". Pain 153 (12): 2315–2324. December 2012. doi:10.1016/j.pain.2012.07.035. PMID 22998781. 
  5. "The neural basis of drug craving: an incentive-sensitization theory of addiction". Brain Res Brain Res Rev 18 (3): 247–91. 1993. doi:10.1016/0165-0173(93)90013-p. PMID 8401595. 
  6. "Lisdexamfetamine Dimesylate: Prodrug Delivery, Amphetamine Exposure and Duration of Efficacy". Clin Drug Investig 36 (5): 341–56. May 2016. doi:10.1007/s40261-015-0354-y. PMID 27021968. 
  7. "Variables that affect the clinical use and abuse of methylphenidate in the treatment of ADHD". Am J Psychiatry 160 (11): 1909–18. November 2003. doi:10.1176/appi.ajp.160.11.1909. PMID 14594733. 
  8. "A review of the acute subjective effects of MDMA/ecstasy". Addiction 101 (7): 933–47. July 2006. doi:10.1111/j.1360-0443.2006.01423.x. PMID 16771886. 
  9. Griffiths, Roland R.; Roache, John D. (1985). "Abuse Liability of Benzodiazepines:A Review of Human Studies Evaluating Subjective and/or Reinforcing Effects". The Benzodiazepines: Current Standards for Medical Practice. Springer Netherlands. pp. 209–225. doi:10.1007/978-94-009-4886-0_16. ISBN 978-94-010-8663-9. 
  10. Alcohol Craving and Relapse Prediction: Imaging Studies. 2010. PMID 21656973. https://www.ncbi.nlm.nih.gov/books/NBK53355/. 
  11. "Does nicotine do what we think it does? A meta-analytic review of the subjective effects of nicotine in nasal spray and intravenous studies with smokers and nonsmokers". Nicotine Tob Res 7 (3): 317–33. June 2005. doi:10.1080/14622200500125385. PMID 16085500. 
  12. "Reinforcing properties of caffeine: studies in humans and laboratory animals". Pharmacol Biochem Behav 29 (2): 419–27. February 1988. doi:10.1016/0091-3057(88)90180-3. PMID 3283780.