Chemistry:Liranaftate
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Short description: Chemical compound
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| Trade names | Zefnart |
| Other names | M-732; piritetrate |
| Routes of administration | Topical |
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| Formula | C18H20N2O2S |
| Molar mass | 328.43 g·mol−1 |
Liranaftate (trade name Zefnart) is a topical antifungal drug.[1] It is used as a 2% cream used to treat tinea pedis (athlete's foot), tinea corporis (ringworm), and tinea cruris (jock itch).[2] It was approved for use in Japan in August 2000.[3][4]
Liranaftate works by inhibiting the fungal enzyme squalene epoxidase that is necessary for the fungus to synthesize sterols which are essential for cell membrane integrity.[5]
References
- ↑ "In vitro antifungal activities of luliconazole, a new topical imidazole". Medical Mycology 47 (6): 640–7. 2009. doi:10.1080/13693780802541518. PMID 19115136.
- ↑ "Torii Pharmaceutical to Launch Antifungal Agent for External Use, "ZEFNART SOLUTION 2%", in Japan" (Press release). Torii Pharmaceutical Co. Retrieved June 27, 2021.
- ↑ "Liranaftate". https://drugs.ncats.io/drug/5253IGO5X3.
- ↑ "Liranaftate". Adis Insight. https://adisinsight.springer.com/drugs/800003128.
- ↑ "Liranaftate". https://www.targetmol.com/compound/Liranaftate.
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