Biology:N-myc-interactor
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
N-myc-interactor also known as N-myc and STAT interactor is a protein that in humans is encoded by the NMI gene.[1][2][3]
Function
NMYC interactor (NMI) interacts with NMYC and CMYC (two members of the oncogene Myc family), and other transcription factors containing a Zip, HLH, or HLH-Zip motif. The NMI protein also interacts with all STATs except STAT2 and augments STAT-mediated transcription in response to cytokines IL-2 and IFN-gamma. The NMI mRNA has low expression levels in all human fetal and adult tissues tested except brain and has high expression in cancer cell line-myeloid leukemias.[3]
Interactions
NMI (gene) has been shown to interact with BRCA1,[4] IFI35,[5] Myc,[4] and STAT5A,[2] and TUBA3C.[6]
References
- ↑ "Isolation and characterization of Nmi, a novel partner of Myc proteins". Oncogene 12 (10): 2171–6. Aug 1996. PMID 8668343.
- ↑ 2.0 2.1 "Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling". Cell 96 (1): 121–30. Mar 1999. doi:10.1016/S0092-8674(00)80965-4. PMID 9989503.
- ↑ 3.0 3.1 "Entrez Gene: NMI N-myc (and STAT) interactor". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9111.
- ↑ 4.0 4.1 "A novel tricomplex of BRCA1, Nmi, and c-Myc inhibits c-Myc-induced human telomerase reverse transcriptase gene (hTERT) promoter activity in breast cancer". J. Biol. Chem. 277 (23): 20965–73. June 2002. doi:10.1074/jbc.M112231200. PMID 11916966.
- ↑ "Interferon-inducible Myc/STAT-interacting protein Nmi associates with IFP 35 into a high molecular mass complex and inhibits proteasome-mediated degradation of IFP 35". J. Biol. Chem. 275 (46): 36278–84. November 2000. doi:10.1074/jbc.M006975200. PMID 10950963.
- ↑ "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. October 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
Further reading
- "Interferon-induced upregulation and cytoplasmic localization of Myc-interacting protein Nmi.". J. Interferon Cytokine Res. 18 (9): 767–71. 1998. doi:10.1089/jir.1998.18.767. PMID 9781816.
- "Subcellular localization of interferon-inducible Myc/stat-interacting protein Nmi is regulated by a novel IFP 35 homologous domain.". J. Interferon Cytokine Res. 19 (11): 1245–52. 1999. doi:10.1089/107999099312902. PMID 10574616.
- "Nmi protein interacts with regions that differ between MycN and Myc and is localized in the cytoplasm of neuroblastoma cells in contrast to nuclear MycN.". Oncogene 18 (48): 6810–7. 2000. doi:10.1038/sj.onc.1203090. PMID 10597290.
- "Interferon-alpha induces nmi-IFP35 heterodimeric complex formation that is affected by the phosphorylation of IFP35.". J. Biol. Chem. 275 (28): 21364–71. 2000. doi:10.1074/jbc.M003177200. PMID 10779520.
- "Interferon-inducible Myc/STAT-interacting protein Nmi associates with IFP 35 into a high molecular mass complex and inhibits proteasome-mediated degradation of IFP 35.". J. Biol. Chem. 275 (46): 36278–84. 2000. doi:10.1074/jbc.M006975200. PMID 10950963.
- "Intracellular redistribution of interferon-inducible proteins Nmi and IFP 35 in apoptotic cells.". J. Interferon Cytokine Res. 22 (2): 237–43. 2002. doi:10.1089/107999002753536211. PMID 11911807.
- "A novel tricomplex of BRCA1, Nmi, and c-Myc inhibits c-Myc-induced human telomerase reverse transcriptase gene (hTERT) promoter activity in breast cancer.". J. Biol. Chem. 277 (23): 20965–73. 2002. doi:10.1074/jbc.M112231200. PMID 11916966.
- "[Identification of a protein interacting with apoptin from human leucocyte cDNA library by using yeast two-hybrid screening]". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 34 (3): 369–72. 2002. PMID 12019454.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315–23. 2004. doi:10.1101/gr.2122004. PMID 15231747.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. 2005. doi:10.1038/nature03466. PMID 15815621. Bibcode: 2005Natur.434..724H.
- "STAT1 and Nmi are downstream targets of Ets-1 transcription factor in MCF-7 human breast cancer cell.". FEBS Lett. 579 (18): 3941–6. 2005. doi:10.1016/j.febslet.2005.06.011. PMID 15996661.
- "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "The high-mobility group transcription factor Sox10 interacts with the N-myc-interacting protein Nmi.". J. Mol. Biol. 353 (5): 1033–42. 2005. doi:10.1016/j.jmb.2005.09.013. PMID 16214168.
- "The PH domain containing protein CKIP-1 binds to IFP35 and Nmi and is involved in cytokine signaling.". Cell. Signal. 19 (5): 932–44. 2007. doi:10.1016/j.cellsig.2006.11.002. PMID 17197158.
- "Camptothecin-induced apoptosis is enhanced by Myc and involves PKCdelta signaling.". Int. J. Cancer 121 (8): 1821–9. 2007. doi:10.1002/ijc.22866. PMID 17565738.
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