Biology:ORC3
From HandWiki
| Origin recognition complex (ORC) subunit 3 N-terminus | |||||||||
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| Identifiers | |||||||||
| Symbol | ORC3_N | ||||||||
| Pfam | PF07034 | ||||||||
| InterPro | IPR010748 | ||||||||
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 Generic protein structure example |
Origin recognition complex subunit 3 is a protein that in humans is encoded by the ORC3 (ORC3L) gene.[1][2][3]
Function
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Studies of a similar gene in Drosophila suggested a possible role of this protein in neuronal proliferation and olfactory memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene.[3]
Interactions
ORC3 has been shown to interact with:
References
- ↑ "The Orc4p and Orc5p subunits of the Xenopus and human origin recognition complex are related to Orc1p and Cdc6p". The Journal of Biological Chemistry 273 (49): 32421–9. Dec 1998. doi:10.1074/jbc.273.49.32421. PMID 9829972.
- ↑ 2.0 2.1 2.2 2.3 "latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant". Neuron 23 (1): 45–54. May 1999. doi:10.1016/S0896-6273(00)80752-7. PMID 10402192.
- ↑ 3.0 3.1 "Entrez Gene: ORC3L origin recognition complex, subunit 3-like (yeast)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23595.
- ↑ 4.0 4.1 4.2 4.3 4.4 "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". Journal of Molecular Biology 327 (1): 111–28. Mar 2003. doi:10.1016/s0022-2836(03)00079-2. PMID 12614612.
- ↑ 5.0 5.1 5.2 "Architecture of the human origin recognition complex". The Journal of Biological Chemistry 276 (31): 29067–71. Aug 2001. doi:10.1074/jbc.M103078200. PMID 11395502.
- ↑ "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage". Science 316 (5828): 1160–6. May 2007. doi:10.1126/science.1140321. PMID 17525332.
- ↑ 7.0 7.1 7.2 7.3 "Assembly of the human origin recognition complex". The Journal of Biological Chemistry 276 (28): 26666–73. Jul 2001. doi:10.1074/jbc.M102493200. PMID 11323433.
Further reading
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. Jan 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. Oct 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "Identification and chromosomal localization of murine ORC3, a new member of the mouse origin recognition complex". Cytogenetics and Cell Genetics 87 (3–4): 245–51. 2000. doi:10.1159/000015435. PMID 10702681.
- "Subsets of human origin recognition complex (ORC) subunits are expressed in non-proliferating cells and associate with non-ORC proteins". The Journal of Biological Chemistry 275 (45): 35233–41. Nov 2000. doi:10.1074/jbc.M005765200. PMID 10954718.
- "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research 11 (3): 422–35. Mar 2001. doi:10.1101/gr.GR1547R. PMID 11230166.
- "Assembly of the human origin recognition complex". The Journal of Biological Chemistry 276 (28): 26666–73. Jul 2001. doi:10.1074/jbc.M102493200. PMID 11323433.
- "Architecture of the human origin recognition complex". The Journal of Biological Chemistry 276 (31): 29067–71. Aug 2001. doi:10.1074/jbc.M103078200. PMID 11395502.
- "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". Journal of Molecular Biology 327 (1): 111–28. Mar 2003. doi:10.1016/S0022-2836(03)00079-2. PMID 12614612.
- "Self-assembling protein microarrays". Science 305 (5680): 86–90. Jul 2004. doi:10.1126/science.1097639. PMID 15232106.
- "Ku80 binds to human replication origins prior to the assembly of the ORC complex". Biochemistry 44 (21): 7885–96. May 2005. doi:10.1021/bi047327n. PMID 15910003.
- "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage". Science 316 (5828): 1160–6. May 2007. doi:10.1126/science.1140321. PMID 17525332.
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