Biology:ORC2
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
| Origin recognition complex subunit 2 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | ORC2 | ||||||||
| Pfam | PF04084 | ||||||||
| InterPro | IPR007220 | ||||||||
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Origin recognition complex subunit 2 is a protein that is encoded by the ORC2 (ORC2L) gene in humans.[1][2]
Function
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. This protein forms a core complex with ORC3, ORC4, and ORC5. It also interacts with CDC45L and MCM10, which are proteins known to be important for the initiation of DNA replication. This protein has been demonstrated to specifically associate with the origin of replication of Epstein-Barr virus in human cells, and is thought to be required for DNA replication from viral origin of replication.[2]
Interactions
ORC2 has been shown to interact with:
- CDC6,[3][4]
- DBF4,[3]
- MCM10,[5]
- MCM2[3]
- MCM4,[3]
- MCM5,[3]
- MCM6,[3]
- MCM7,[3]
- ORC1,[3][6][7][8]
- ORC3,[3][7][9][10][11]
- ORC4,[3][7][9][12]
- ORC5,[3][7][9][13]
- ORC6,[3][7] and
- Replication protein A1.[3]
References
- ↑ "Mouse and human homologues of the yeast origin of replication recognition complex subunit ORC2 and chromosomal localization of the cognate human gene ORC2L". Genomics 31 (1): 119–122. October 1996. doi:10.1006/geno.1996.0018. PMID 8808289.
- ↑ 2.0 2.1 "Entrez Gene: ORC2L origin recognition complex, subunit 2-like (yeast)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4999.
- ↑ 3.00 3.01 3.02 3.03 3.04 3.05 3.06 3.07 3.08 3.09 3.10 3.11 3.12 "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". J. Mol. Biol. 327 (1): 111–28. March 2003. doi:10.1016/s0022-2836(03)00079-2. PMID 12614612.
- ↑ "Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis". Mol. Cell. Biol. 20 (22): 8602–12. November 2000. doi:10.1128/mcb.20.22.8602-8612.2000. PMID 11046155.
- ↑ "The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase". Nucleic Acids Res. 28 (23): 4769–77. December 2000. doi:10.1093/nar/28.23.4769. PMID 11095689.
- ↑ "Nuclear organization of DNA replication initiation proteins in mammalian cells". J. Biol. Chem. 277 (12): 10354–61. March 2002. doi:10.1074/jbc.M111398200. PMID 11779870.
- ↑ 7.0 7.1 7.2 7.3 7.4 "Assembly of the human origin recognition complex". J. Biol. Chem. 276 (28): 26666–73. July 2001. doi:10.1074/jbc.M102493200. PMID 11323433.
- ↑ "Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication". Mol. Cell 9 (3): 481–91. March 2002. doi:10.1016/s1097-2765(02)00467-7. PMID 11931757.
- ↑ 9.0 9.1 9.2 "Architecture of the human origin recognition complex". J. Biol. Chem. 276 (31): 29067–71. August 2001. doi:10.1074/jbc.M103078200. PMID 11395502.
- ↑ "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage". Science 316 (5828): 1160–6. May 2007. doi:10.1126/science.1140321. PMID 17525332. Bibcode: 2007Sci...316.1160M.
- ↑ "latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant". Neuron 23 (1): 45–54. May 1999. doi:10.1016/s0896-6273(00)80752-7. PMID 10402192.
- ↑ "Identification of HsORC4, a member of the human origin of replication recognition complex". J. Biol. Chem. 272 (45): 28247–51. November 1997. doi:10.1074/jbc.272.45.28247. PMID 9353276.
- ↑ "ORC5L, a new member of the human origin recognition complex, is deleted in uterine leiomyomas and malignant myeloid diseases". J. Biol. Chem. 273 (42): 27137–45. October 1998. doi:10.1074/jbc.273.42.27137. PMID 9765232.
Further reading
- "Conserved initiator proteins in eukaryotes". Science 270 (5242): 1667–1671. 1996. doi:10.1126/science.270.5242.1667. PMID 7502077.
- "The human homolog of Saccharomyces cerevisiae CDC45". J. Biol. Chem. 273 (29): 18205–18209. 1998. doi:10.1074/jbc.273.29.18205. PMID 9660782.
- "Human minichromosome maintenance proteins and human origin recognition complex 2 protein on chromatin". J. Biol. Chem. 273 (38): 24543–24549. 1998. doi:10.1074/jbc.273.38.24543. PMID 9733749.
- "latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant". Neuron 23 (1): 45–54. 1999. doi:10.1016/S0896-6273(00)80752-7. PMID 10402192.
- "Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication". EMBO J. 18 (20): 5703–5713. 1999. doi:10.1093/emboj/18.20.5703. PMID 10523313.
- "Selective instability of Orc1 protein accounts for the absence of functional origin recognition complexes during the M-G(1) transition in mammals". EMBO J. 19 (11): 2728–2738. 2000. doi:10.1093/emboj/19.11.2728. PMID 10835370.
- "Subsets of human origin recognition complex (ORC) subunits are expressed in non-proliferating cells and associate with non-ORC proteins". J. Biol. Chem. 275 (45): 35233–35241. 2001. doi:10.1074/jbc.M005765200. PMID 10954718.
- "The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase". Nucleic Acids Res. 28 (23): 4769–4777. 2001. doi:10.1093/nar/28.23.4769. PMID 11095689.
- "Assembly of the human origin recognition complex". J. Biol. Chem. 276 (28): 26666–26673. 2001. doi:10.1074/jbc.M102493200. PMID 11323433.
- "Architecture of the human origin recognition complex". J. Biol. Chem. 276 (31): 29067–29071. 2001. doi:10.1074/jbc.M103078200. PMID 11395502.
- "Replication from oriP of Epstein-Barr virus requires human ORC and is inhibited by geminin". Cell 106 (3): 287–296. 2001. doi:10.1016/S0092-8674(01)00458-5. PMID 11509178.
- "Cell cycle-dependent proteolysis and phosphorylation of human Mcm10". J. Biol. Chem. 276 (51): 48526–31. 2002. doi:10.1074/jbc.M107190200. PMID 11602595.
- "Nuclear organization of DNA replication initiation proteins in mammalian cells". J. Biol. Chem. 277 (12): 10354–10361. 2002. doi:10.1074/jbc.M111398200. PMID 11779870.
- "Human Mcm proteins at a replication origin during the G1 to S phase transition". Nucleic Acids Res. 30 (19): 4176–4185. 2002. doi:10.1093/nar/gkf532. PMID 12364596.
- "Ku antigen, an origin-specific binding protein that associates with replication proteins, is required for mammalian DNA replication". Biochim. Biophys. Acta 1578 (1–3): 59–72. 2002. doi:10.1016/S0167-4781(02)00497-9. PMID 12393188.
- "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". J. Mol. Biol. 327 (1): 111–128. 2003. doi:10.1016/S0022-2836(03)00079-2. PMID 12614612.
External links
- PDBe-KB provides an overview of all the structure information available in the PDB for Human Origin recognition complex subunit 2 (ORC2)
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