Biology:FKBP2
 Generic protein structure example |
FK506-binding protein 2 is a protein that in humans is encoded by the FKBP2 gene.[1][2]
Function
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is thought to function as an ER chaperone and may also act as a component of membrane cytoskeletal scaffolds. This gene has two alternatively spliced transcript variants that encode the same isoform. Multiple polyadenylation sites have been described for this gene, but the full length nature of this gene has not been determined.[2]
Interactions
FKBP2 has been shown to interact with ARFGEF1[3] and EPB41L2.[4]
References
- ↑ "Molecular cloning of a membrane-associated human FK506- and rapamycin-binding protein, FKBP-13". Proc. Natl. Acad. Sci. U.S.A. 88 (15): 6677–81. Sep 1991. doi:10.1073/pnas.88.15.6677. PMID 1713687. Bibcode: 1991PNAS...88.6677J.
- ↑ 2.0 2.1 "Entrez Gene: FKBP2 FK506 binding protein 2, 13kDa". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2286.
- ↑ "Interaction of FK506-binding protein 13 with brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1): effects of FK506". Proc. Natl. Acad. Sci. U.S.A. 100 (5): 2322–7. Mar 2003. doi:10.1073/pnas.2628047100. PMID 12606707. Bibcode: 2003PNAS..100.2322P.
- ↑ "The 13-kD FK506 binding protein, FKBP13, interacts with a novel homologue of the erythrocyte membrane cytoskeletal protein 4.1". J. Cell Biol. 141 (1): 143–53. Apr 1998. doi:10.1083/jcb.141.1.143. PMID 9531554.
Further reading
- "Chromosomal band assignments of the genes encoding human FKBP12 and FKBP13". Biochem. Biophys. Res. Commun. 189 (2): 819–23. 1992. doi:10.1016/0006-291X(92)92276-4. PMID 1281998.
- "Structural organization of the genes encoding human and murine FK506-binding protein (FKBP) 13 and comparison to FKBP1". Gene 134 (2): 271–5. 1993. doi:10.1016/0378-1119(93)90106-D. PMID 7505249.
- "Induction of the FK506-binding protein, FKBP13, under conditions which misfold proteins in the endoplasmic reticulum". Biochem. J. 303 (Pt 3): 705–8. 1994. doi:10.1042/bj3030705. PMID 7526846.
- "Localization of the FK506-binding protein, FKBP 13, to the lumen of the endoplasmic reticulum". Biochem. J. 294 (Pt 2): 511–5. 1993. doi:10.1042/bj2940511. PMID 8373365.
- "The 13-kD FK506 binding protein, FKBP13, interacts with a novel homologue of the erythrocyte membrane cytoskeletal protein 4.1". J. Cell Biol. 141 (1): 143–53. 1998. doi:10.1083/jcb.141.1.143. PMID 9531554.
- "Interaction of FK506-binding protein 13 with brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1): effects of FK506". Proc. Natl. Acad. Sci. U.S.A. 100 (5): 2322–7. 2003. doi:10.1073/pnas.2628047100. PMID 12606707. Bibcode: 2003PNAS..100.2322P.
- "Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein". Science 302 (5651): 1769–72. 2003. doi:10.1126/science.1090389. PMID 14657499. Bibcode: 2003Sci...302.1769W.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell 125 (4): 801–14. 2006. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
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