Biology:FKBPL
 Generic protein structure example |
FK506-binding protein like, also known as FKBPL, is a protein that in humans is encoded by the FKBPL gene.[1]
Function
FKBPL has similarity to the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The encoded protein is thought to have a potential role in the induced radioresistance. Also it appears to have some involvement in the control of the cell cycle.[2]
FKBPL is involved in cellular response to stress. It was first isolated in 1999 and was initially named DIR1.[3] It was later reclassified because of its homology to the FKBP family of proteins and was renamed FKBP-like (FKBPL). A separate study that found it to be involved in the stabilisation of newly synthesised p21 termed it Wisp39.[4]
It is known to interact with Hsp90, glucocorticoid receptor and dynamitin and may play a role in signalling, like other FKBPs.[5]
FKBPL has also been shown to influence estrogen receptor signalling and can have a determinant effect on response to the breast cancer drug tamoxifen.[6]
References
- ↑ "Gene regulation by low-dose ionizing radiation in a normal human lung epithelial cell line". Biochem. Soc. Trans. 25 (1): 335–42. February 1997. doi:10.1042/bst0250335. PMID 9056895.
- ↑ "Entrez Gene: FKBPL". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=63943.
- ↑ "A novel human stress response-related gene with a potential role in induced radioresistance". Radiat. Res. 152 (5): 451–61. November 1999. doi:10.2307/3580140. PMID 10521921. Bibcode: 1999RadR..152..451R.
- ↑ "Regulation of p21(WAF1/CIP1) stability by WISp39, a Hsp90 binding TPR protein". Mol. Cell 17 (2): 237–49. January 2005. doi:10.1016/j.molcel.2004.11.049. PMID 15664193.
- ↑ "A novel FK506-like binding protein (FKBPL) interacts with the glucocorticoid receptor and regulates steroid receptor signalling". Endocrinology 149 (11): 5724–34. July 2008. doi:10.1210/en.2008-0168. PMID 18669603.
- ↑ "FKBPL regulates estrogen receptor signaling and determines response to endocrine therapy". Cancer Res. 70 (3): 1090–100. February 2010. doi:10.1158/0008-5472.CAN-09-2515. PMID 20103631.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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