Medicine:Cerebral arteriovenous malformation
Cerebral arteriovenous malformation | |
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Large arteriovenous malformation of the parietal lobe |
A cerebral arteriovenous malformation (cerebral AVM, CAVM, cAVM, brain AVM, or BAVM) is an abnormal connection between the arteries and veins in the brain—specifically, an arteriovenous malformation in the cerebrum.[1]
Signs and symptoms
The most frequently observed problems related to a cerebral arteriovenous malformation (AVM) are headaches and seizures, cranial nerve afflictions including pinched nerve and palsy,[2][3] backaches, neckaches, and nausea from coagulated blood that has made its way down to be dissolved in the cerebrospinal fluid. Perhaps 15% of the population at detection are asymptomatic.[3] Other common symptoms are a pulsing noise in the head, progressive weakness, numbness and vision changes as well as debilitating, excruciating pain.[4][5]
In serious cases, blood vessels rupture and cause bleeding within the brain (intracranial hemorrhage).[lower-alpha 1] In more than half of patients with AVM, this is the first symptom.[7] Symptoms due to bleeding include loss of consciousness, sudden and severe headache, nausea, vomiting, incontinence, and blurred vision, amongst others.[4] Impairments caused by local brain-tissue damage on the bleed site are also possible, including seizure, one-sided weakness (hemiparesis), a loss of touch sensation on one side of the body and deficits in language processing (aphasia).[4] Ruptured AVMs are responsible for considerable mortality and morbidity.[8]
AVMs in certain critical locations may stop the circulation of the cerebrospinal fluid, causing it to accumulate within the skull and giving rise to a clinical condition called hydrocephalus.[5] A stiff neck can occur as the result of increased pressure within the skull and irritation of the meninges.[9]
Pathophysiology
A cerebral AVM is an abnormal anastomosis (connection) between the arteries and veins in the human brain and are most commonly of prenatal origin.[10] In a normal brain, oxygen-enriched blood from the heart travels in sequence through smaller blood vessels going from arteries, to arterioles and then capillaries.[10] Oxygen is removed in the capillaries to be used by the brain.[10] After the oxygen is removed, blood reaches venules and later veins which will take it back to the heart and lungs.[10] A cerebral AVM causes blood to travel from arteries to veins through the abnormal connections, disrupting normal circulation.[10][11]
Diagnosis
File:Vein of Galen aneurysmal malformations.TIF
A cerebral AVM diagnosis is established by neuroimaging studies after a complete neurological and physical examination.[5][12] Three main techniques are used to visualize the brain and search for an AVM: computed tomography (CT), magnetic resonance imaging (MRI), and cerebral angiography.[12] A CT scan of the head is usually performed first when the subject is symptomatic. It can suggest the approximate site of the bleed.[3] MRI is more sensitive than CT in the diagnosis, and provides better information about the exact location of the malformation.[12] More detailed pictures of the tangle of blood vessels that compose an AVM can be obtained by using radioactive agents injected into the blood stream. If a CT is used in conjunction with an angiogram, this is called a computerized tomography angiogram; while, if MRI is used it is called magnetic resonance angiogram.[3][12] The best images of a cerebral AVM are obtained through cerebral angiography. This procedure involves using a catheter, threaded through an artery up to the head, to deliver a contrast agent into the AVM. As the contrast agent flows through the AVM structure, a sequence of X-ray images are obtained.[12]
Grading
Spetzler-Martin (SM) Grade
A common method of grading cerebral AVMs is the Spetzler-Martin (SM) grade.[13] This system was designed to assess the patient's risk of neurological deficit after open surgical resection (surgical morbidity), based on characteristics of the AVM itself. Based on this system, AVMs may be classified as grades 1–5. This system was not intended to characterize risk of hemorrhage.[14]
AVM size | Adjacent eloquent cortex | Draining veins |
---|---|---|
< 3 cm = 1 | Non-eloquent = 0 | Superficial only = 0 |
3 – 6 cm = 2 | Eloquent* = 1 | Deep veins = 1 |
> 6 cm = 3 |
"Eloquent" is defined as areas within the brain that, if removed will result in loss of sensory processing or linguistic ability, minor paralysis, or paralysis. These include the basal ganglia, language cortices, sensorimotor regions, and white matter tracts.[15] Importantly, eloquent areas are often defined differently across studies[16] where deep cerebellar nuclei, cerebral peduncles, thalamus, hypothalamus, internal capsule, brainstem, and the visual cortex could be included.
The risk of post-surgical neurological deficit (difficulty with language, motor weakness, vision loss) increases with increasing Spetzler-Martin grade.[17]
Supplemented Spetzler-Martin (SM-supp, Lawton-Young) Grade
A limitation of the Spetzler-Martin Grading system is that it does not include the following factors: Patient age, hemorrhage, diffuseness of nidus, and arterial supply. In 2010 a new supplemented Spetzler-Martin system (SM-supp, Lawton-Young) was devised adding these variables to the SM system. Under this new system AVMs are classified from grades 1–10. It has since been determined to have greater predictive accuracy than SM grades alone.[18]
Variable | Spetzler-Martin Grading Scale | Supplemental Grading Scale | ||
---|---|---|---|---|
Definition | Points | Definition | Points | |
AVM size | < 3 cm | 1 | ||
3 – 6 cm | 2 | |||
> 6 cm | 3 | |||
Deep venous drainage | No | 0 | ||
Yes | 1 | |||
Eloquence | No | 0 | ||
Yes | 1 | |||
SM Grade Subtotal | (1 - 5) | |||
Age | < 20 years | 1 | ||
20 – 40 years | 2 | |||
> 40 years | 3 | |||
Unruptured presentation | No | 0 | ||
Yes | 1 | |||
Diffuse | No | 0 | ||
Yes | 1 | |||
SM-Supp Grade Subtotal | (1 – 5) | |||
SM-Supp Total | (1 – 10) |
Treatment
Treatment depends on the location and size of the AVM and whether there is bleeding or not.[19]
The treatment in the case of sudden bleeding is focused on restoration of vital function.[20]
Medical
Anticonvulsant medications such as phenytoin are often used to control seizure; medications or procedures may be employed to relieve intracranial pressure. Eventually, curative treatment may be required to prevent recurrent hemorrhage. However, any type of intervention may also carry a risk of creating a neurological deficit.[21]
Surgical
Surgical elimination of the blood vessels involved is the preferred curative treatment for many types of AVM.[19] Surgery is performed by a neurosurgeon who temporarily removes part of the skull (craniotomy), separates the AVM from surrounding brain tissue, and resects the abnormal vessels.[19] While surgery can result in an immediate, complete removal of the AVM, risks exist depending on the size and the location of the malformation. The AVM must be resected en bloc, for partial resection will likely cause severe hemorrhage.[8] The preferred treatment of Spetzler-Martin grade 1 and 2 AVMs in young, healthy patients is surgical resection due to the relatively small risk of neurological damage compared to the high lifetime risk of hemorrhage. Grade 3 AVMs may or may not be amenable to surgery. Grade 4 and 5 AVMs are not usually surgically treated.[22]
Radiosurgical
Radiosurgery has been widely used on small AVMs with considerable success. The Gamma Knife is an apparatus used to precisely apply a controlled radiation dosage to the volume of the brain occupied by the AVM. While this treatment does not require an incision and craniotomy (with their own inherent risks), three or more years may pass before the complete effects are known, during which time patients are at risk of bleeding.[19] Complete obliteration of the AVM may or may not occur after several years, and repeat treatment may be needed. Radiosurgery is itself not without risk. In one large study, nine percent of patients had transient neurological symptoms, including headache, after radiosurgery for AVM. However, most symptoms resolved, and the long-term rate of neurological symptoms was 3.8%.[23]
Neuroendovascular therapy
Embolization is performed by interventional neuroradiologists and the occlusion of blood vessels most commonly is obtained with ethylene vinyl alcohol copolymer (Onyx) or n-butyl cyanoacrylate. These substances are introduced by a radiographically guided catheter, and block vessels responsible for blood flow into the AVM.[24] Embolization is frequently used as an adjunct to either surgery or radiation treatment.[19] Embolization reduces the size of the AVM and during surgery it reduces the risk of bleeding.[19] However, embolization alone may completely obliterate some AVMs. In high flow intranidal fistulas balloons can also be used to reduce the flow so that embolization can be done safely.[25]
Risks
A first-of-its-kind controlled clinical trial by the National Institutes of Health and National Institute of Neurological Disorders and Stroke focuses on the risk of stroke or death in patients with an AVM who either did or did not undergo interventional eradication.[26] Early results suggest that the invasive treatment of unruptured AVMs tends to yield worse results than the therapeutic (medical) management of symptoms.[27][lower-alpha 2] Because of the higher-than-expected experimental event rate (e.g. stroke or death), patient enrollment was halted by May 2013, while the study intended to follow participants (over a planned 5 to 10 years) to determine which approach seems to produce better long-term results.[27]
Prognosis
The main risk is intracranial hemorrhage. This risk is difficult to quantify since many patients with asymptomatic AVMs will never come to medical attention. Small AVMs tend to bleed more often than do larger ones, the opposite of cerebral aneurysms.[28] If a rupture or bleeding incident occurs, the blood may penetrate either into the brain tissue (cerebral hemorrhage) or into the subarachnoid space, which is located between the sheaths (meninges) surrounding the brain (subarachnoid hemorrhage). Bleeding may also extend into the ventricular system (intraventricular hemorrhage). Cerebral hemorrhage appears to be most common.[3] One long-term study (mean follow up greater than 20 years) of over 150 symptomatic AVMs (either presenting with bleeding or seizures) found the risk of cerebral hemorrhage to be approximately 4% per year, slightly higher than the 2–4% seen in other studies.[29][6] The earlier an AVM appears, the more likely it is to cause hemorrhage over one's lifetime; e.g. (assuming a 3% annual risk), an AVM appearing at 25 years of age indicates a 79% lifetime chance of hemorrhage, while one appearing at age 85 indicates only a 17% chance.[6] Ruptured AVMs are a significant source of morbidity and mortality; following a rupture, as many as 29% of patients will die, with only 55% able to live independently.[8]
Epidemiology
The annual new detection rate incidence of AVMs is approximately 1 per 100,000 a year. The point prevalence in adults is approximately 18 per 100,000.[3] AVMs are more common in males than females, although in females pregnancy may start or worsen symptoms due to the increase in blood flow and volume it usually brings.[30] There is a significant preponderance (15–20%) of AVM in patients with hereditary hemorrhagic telangiectasia (Osler–Weber–Rendu syndrome).[6]
References
Footnotes
Citations
- ↑ "Brain AVM (arteriovenous malformation) - Symptoms and causes" (in en). https://www.mayoclinic.org/diseases-conditions/brain-avm/symptoms-causes/syc-20350260.
- ↑ Al-Saiegh, Fadi; Hines, Kevin (28 June 2019). "Oculomotor neuropathy from an unruptured arteriovenous malformation in the frontal operculum: A case report" (in en-US). http://surgicalneurologyint.com/surgicalint-articles/oculomotor-neuropathy-from-an-unruptured-arteriovenous-malformation-in-the-frontal-operculum-a-case-report-2/.
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 "A systematic review of the frequency and prognosis of arteriovenous malformations of the brain in adults". Brain 124 (Pt 10): 1900–26. October 2001. doi:10.1093/brain/124.10.1900. PMID 11571210.
- ↑ 4.0 4.1 4.2 Mayo Clinic staff (February 2009). "Brain AVM (arteriovenous malformation)-Symptoms". Mayo Clinic. http://www.mayoclinic.com/health/brain-avm/DS01126/DSECTION=symptoms.
- ↑ 5.0 5.1 5.2 "Arteriovenous malformation - cerebral". ADAM. October 2008. https://www.nlm.nih.gov/medlineplus/ency/article/000779.htm.
- ↑ 6.0 6.1 6.2 6.3 6.4 Greenberg, Mark (2006). Handbook of Neurosurgery (6th ed.). Thieme. pp. 835–837. https://archive.org/details/handbookofneuros0006gree/page//.
- ↑ Perret, G.; Nishioka, H. (1966-10-01). "Report on the cooperative study of intracranial aneurysms and subarachnoid hemorrhage. Section VI. Arteriovenous malformations. An analysis of 545 cases of cranio-cerebral arteriovenous malformations and fistulae reported to the cooperative study". Journal of Neurosurgery 25 (4): 467–490. doi:10.3171/jns.1966.25.4.0467. ISSN 0022-3085. PMID 5925721.
- ↑ 8.0 8.1 8.2 Jandial, Rahul (2017). 100 Case Reviews in Neurosurgery. Elsevier. ISBN 978-0-323-35637-4.
- ↑ "Meningitis and stiff neck: Causes, treatment, and more" (in en). 2021-09-21. https://www.medicalnewstoday.com/articles/meningitis-stiff-neck.
- ↑ 10.0 10.1 10.2 10.3 10.4 Mayo Clinic staff (February 2009). "Brain AVM (arteriovenous malformation)-Causes". Mayo Clinic. http://www.mayoclinic.com/health/brain-avm/DS01126/DSECTION=causes.
- ↑ Mouchtouris, Nikolaos; Jabbour, Pascal M; Starke, Robert M; Hasan, David M; Zanaty, Mario; Theofanis, Thana; Ding, Dale; Tjoumakaris, Stavropoula I et al. (19 November 2014). "Biology of cerebral arteriovenous malformations with a focus on inflammation". Journal of Cerebral Blood Flow & Metabolism 35 (2): 167–175. doi:10.1038/jcbfm.2014.179. PMID 25407267.
- ↑ 12.0 12.1 12.2 12.3 12.4 Mayo Clinic staff (February 2009). "Brain AVM (arteriovenous malformation)-Tests and diagnosis". Mayo Clinic. http://www.mayoclinic.com/health/brain-avm/DS01126/DSECTION=tests-and-diagnosis.
- ↑ Spetzler, R; Martin N (1986). "A proposed grading system for arteriovenous malformations". J Neurosurg 65 (4): 476–83. doi:10.3171/jns.1986.65.4.0476. PMID 3760956.
- ↑ "Spetzler Martin Grading Scale". https://www.bmc.org/spetzler-martin-grading-scale#:~:text=The%20Spetzler%20Martin%20Grading%20Scale,and%20low%20risk%20for%20surgery..
- ↑ Jakola, Asgeir S.; Unsgård, Geirmund; Myrmel, Kristin S.; Kloster, Roar; Torp, Sverre H.; Lindal, Sigurd; Solheim, Ole (2012-12-10). "Low Grade Gliomas in Eloquent Locations – Implications for Surgical Strategy, Survival and Long Term Quality of Life" (in en). PLOS One 7 (12): e51450. doi:10.1371/journal.pone.0051450. ISSN 1932-6203. PMID 23251537. Bibcode: 2012PLoSO...751450J.
- ↑ Satoer, Djaina; Visch-Brink, Evy; Dirven, Clemens; Vincent, Arnaud (2016-01-01). "Glioma surgery in eloquent areas: can we preserve cognition?" (in en). Acta Neurochirurgica 158 (1): 35–50. doi:10.1007/s00701-015-2601-7. ISSN 0942-0940. PMID 26566782. PMC 4684586. https://doi.org/10.1007/s00701-015-2601-7.
- ↑ "Brain arteriovenous malformations". Wolters Kluwer. https://www.uptodate.com/contents/brain-arteriovenous-malformations. "A higher Spetzler-Martin grading scale score correlates with increased risk of surgical morbidity and neurologic deficits."
- ↑ Kim, Helen; Abla, Adib A.; Nelson, Jeffrey; McCulloch, Charles E.; Bervini, David; Morgan, Michael K.; Stapleton, Christopher; Walcott, Brian P. et al. (2015-01-01). "Validation of the Supplemented Spetzler-Martin Grading System for Brain Arteriovenous Malformations in a Multicenter Cohort of 1009 Surgical Patients" (in en). Neurosurgery 76 (1): 25–33. doi:10.1227/neu.0000000000000556. ISSN 0148-396X. PMID 25251197.
- ↑ 19.0 19.1 19.2 19.3 19.4 19.5 Mayo Clinic staff (February 2009). "Brain AVM (arteriovenous malformation)-Treatments and drugs". Mayo Clinic. http://www.mayoclinic.com/health/brain-avm/DS01126/DSECTION=treatments-and-drugs.
- ↑ "Arteriovenous Malformation - Conditions - For Patients - UR Neurosurgery". https://www.urmc.rochester.edu/neurosurgery/services/conditions/arteriovenous.aspx.
- ↑ "AANS | Arteriovenous Malformations" (in en). http://www.aans.org/Patients/Neurosurgical-Conditions-and-Treatments/Arteriovenous-Malformations.
- ↑ Starke, RM (2009). "Treatment guidelines for cerebral arteriovenous malformation microsurgery". Br J Neurosurg 23 (4): 376–86. doi:10.1080/02688690902977662. PMID 19637008.
- ↑ Flickinger, JC (1998). "Analysis of neurological sequelae from radiosurgery of arteriovenous malformations: How location affects outcome". Int J Radiat Oncol Biol Phys 40 (2): 273–278. doi:10.1016/S0360-3016(97)00718-9. PMID 9457809.
- ↑ Ellis, Jason A.; Lavine, Sean D. (2014-01-01). "Role of Embolization for Cerebral Arteriovenous Malformations". Methodist DeBakey Cardiovascular Journal 10 (4): 234–239. doi:10.14797/mdcj-10-4-234. ISSN 1947-6094. PMID 25624978.
- ↑ Huded V. Endovascular balloon-assisted glue embolization of intranidal high flow fistula in brain AVM. J Neurosci Rural Pract 2013;4, Suppl S1:148-9
- ↑ Mohr, Jay Preston (June 4, 2015). Columbia University. "A Randomized Trial of Unruptured Brain Arteriovenous Malformations". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT00389181. Retrieved 2023-03-06.
- ↑ 27.0 27.1 "A Randomized Trial of Unruptured Brain Arteriovenous Malformations (ARUBA)". January 29, 2014. http://www.ninds.nih.gov/news_and_events/news_articles/ARUBA_trial_results.htm.
- ↑ Crawford, PM (1986). "Arteriovenous malformations of the brain: natural history in unoperated patients". J Neurol Neurosurg Psychiatry 49 (1): 1–10. doi:10.1136/jnnp.49.1.1. PMID 3958721.
- ↑ Ondra, SL (1990). "The natural history of symptomatic arteriovenous malformations of the brain: A 24-year follow-up assessment". J Neurosurg 73 (3): 387–391. doi:10.3171/jns.1990.73.3.0387. PMID 2384776.
- ↑ Mayo Clinic staff (February 2009). "Brain AVM (arteriovenous malformation)-Risk factors". Mayo Clinic. http://www.mayoclinic.com/health/brain-avm/DS01126/DSECTION=risk-factors.
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![]() | Original source: https://en.wikipedia.org/wiki/Cerebral arteriovenous malformation.
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