Chemistry:Peptide T

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Peptide T
Peptide T.svg
Names
IUPAC name
L-Alanyl-L-seryl-L-threonyl-L-threonyl-L-threonyl-L-asparaginyl-L-tyrosyl-L-threonine
Identifiers
3D model (JSmol)
ChemSpider
UNII
Properties
C35H55N9O16
Molar mass 857.872 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
Tracking categories (test):

Peptide T is an HIV entry inhibitor discovered in 1986 by Candace Pert and Michael Ruff, a US neuroscientist and immunologist.[1] Peptide T, and its modified analog Dala1-peptide T-amide (DAPTA), a drug in clinical trials, is a short peptide derived from the HIV envelope protein gp120 which blocks binding[2] and infection[3] of viral strains which use the CCR5 receptor to infect cells.

Peptide T has several positive effects related to HIV disease and Neuro-AIDS.[4] A FDG-PET neuro-imaging study in an individual with AIDS dementia who completed a 12-wk treatment with intranasal DAPTA, showed remission in 34 out of 35 brain regions after treatment.[5] A placebo-controlled, three site, 200+ patient NIH-funded clinical trial, which focused on neurocognitive improvements, was conducted between 1990 and 1995. The results showed that DAPTA was not significantly different from placebo on the study primary end points. However, 2 of 7 domains, abstract thinking and speed of information processing, did show improvement in the DAPTA group (p<.05). Furthermore, twice as many DAPTA-treated patients improved, whereas twice as many placebo patients deteriorated (P=.02). A sub-group analysis showed that DAPTA had a treatment effect and improved global cognitive performance (P=.02) in the patients who had more severe cognitive impairment.[6]

An analysis of antiviral effects from the 1996 NIH study showed peripheral viral load (combined plasma and serum) was significantly reduced in the DAPTA-treated group.[7] An eleven-person study for peptide T effects on cellular viral load showed reductions in the persistently infected monocyte reservoir to undetectable levels in most of the patients.[8] Elimination of viral reservoirs, such as the persistently infected monocytes or brain microglia, is an important treatment goal.[9]

Peptide T clinical development was stopped due to the propensity of the liquid nasal spray to lose potency upon storage and shifted to its shorter oral analog, the pentapeptide CCR2/CCR5 antagonist RAP-103 (Receptor Active Peptide) for neuropathic pain and neurodegeneration.[10] RAP-103 also blocks CCR8,[11] which may be important in neuropathic pain.[12] Inhibitors of CCR5, including DAPTA,[13][14] prevent and reverse neurodegeneration and are therapeutic targets in stroke/brain injury[15] and dementia, such as in Parkinsons Disease.[16]

Popular culture

In the 2013 biographical film Dallas Buyers Club,[17] protagonist Ron Woodroof (Matthew McConaughey) promotes the use of injected peptide T as a treatment for HIV/AIDS and Alzheimer's disease and sues the FDA over their efforts to limit his ability to use peptide T, as it was an unapproved medicine. Additional information on Woodroof's court challenge to the FDA related to his obtaining access to peptide T can be found in the article by Marsha Cohen in Hastings Constitutional Law Quarterly (vol.18:471) [Cohen, 1991]. Woodroof's challenge was in part responsible for the 1987 revisions to the FDA investigational drug regulations that expanded access to experimental drugs for patients with serious diseases with no alternative therapies.[citation needed]

Psoriasis

A 1991 Stockholm study with 9 patients and no control group found that even small doses of 2 mg of Peptide T given intravenously in 500 ml saline for 28 days, once a day, alleviate psoriasis symptoms by more than 50% in 5 patients, 3 months after the treatment ended.[18]

References

  1. ↑ Pert CB; Hill JM; Ruff MR et al. (Dec 1986). "Octapeptides deduced from the neuropeptide receptor-like pattern of antigen T4 in brain potently inhibit human immunodeficiency virus receptor binding and T-cell infectivity". Proc Natl Acad Sci USA 83 (23): 9254–8. doi:10.1073/pnas.83.23.9254. PMID 3097649. Bibcode: 1986PNAS...83.9254P. 
  2. ↑ "Chemokine receptor-5 (CCR5) is a receptor for the HIV entry inhibitor peptide T (DAPTA)". Antiviral Res. 67 (2): 83–92. Aug 2005. doi:10.1016/j.antiviral.2005.03.007. PMID 16002156. 
  3. ↑ Ruff MR; Melendez-Guerrero LM; Yang QE et al. (Oct 2001). "Peptide T inhibits HIV-1 infection mediated by the chemokine receptor-5 (CCR5)". Antiviral Res. 52 (1): 63–75. doi:10.1016/S0166-3542(01)00163-2. PMID 11530189. 
  4. ↑ "Update on D-ala-peptide T-amide (DAPTA): a viral entry inhibitor that blocks CCR5 chemokine receptors". Curr. HIV Res. 1 (1): 51–67. Jan 2003. doi:10.2174/1570162033352066. PMID 15043212. http://www.bentham-direct.org/pages/content.php?CHR/2003/00000001/00000001/005AB.SGM. 
  5. ↑ "Peptide T and glucose metabolism in AIDS dementia complex". J. Nucl. Med. 37 (7): 1177–80. July 1996. PMID 8965193. 
  6. ↑ "Randomized double-blind placebo-controlled trial of peptide T for HIV-associated cognitive impairment". Arch. Neurol. 55 (1): 41–51. January 1998. doi:10.1001/archneur.55.1.41. PMID 9443710. 
  7. ↑ Goodkin K; Vitiello B; Lyman WD et al. (Jun 2006). "Cerebrospinal and peripheral human immunodeficiency virus type 1 load in a multisite, randomized, double-blind, placebo-controlled trial of D-Ala1-peptide T-amide for HIV-1-associated cognitive-motor impairment". J. Neurovirol. 12 (3): 178–89. doi:10.1080/13550280600827344. PMID 16877299. 
  8. ↑ Polianova MT; Ruscetti FW; Pert CB et al. (Jul 2003). "Antiviral and immunological benefits in HIV patients receiving intranasal peptide T (DAPTA)". Peptides 24 (7): 1093–8. doi:10.1016/S0196-9781(03)00176-1. PMID 14499289. 
  9. ↑ "HIV-1 can be recovered from a variety of cells including peripheral blood monocytes of patients receiving highly active antiretroviral therapy: a further obstacle to eradication". J. Leukoc. Biol. 68 (3): 345–50. Sep 2000. PMID 10985250. http://www.jleukbio.org/cgi/pmidlookup?view=long&pmid=10985250. 
  10. ↑ Padi SSV; Shi, X. Q.; Zhao, Y. Q.; Ruff, M. R.; Baichoo, N.; Pert, C. B.; Zhang, J. (2012). "Attenuation of rodent neuropathic pain by an orally active peptide, RAP-103, which potently blocks CCR2- and CCR5-mediated monocyte chemotaxis and inflammation". Pain 153 (1): 95–106. doi:10.1016/j.pain.2011.09.022. PMID 22033364. https://pubmed.ncbi.nlm.nih.gov/22033364/. 
  11. ↑ Noda, M.; Tomonaga, D.; Kitazono, K.; Yoshioka, Y.; Liu, J.; Rousseau, J. P.; Kinkead, R.; Ruff, M. R. et al. (2018). "Neuropathic pain inhibitor, RAP-103, is a potent inhibitor of microglial CCL1/CCR8". Neurochemistry International 119: 184–189. doi:10.1016/j.neuint.2017.12.005. PMID 29248693. https://pubmed.ncbi.nlm.nih.gov/29248693/. 
  12. ↑ Zychowska, M.; Rojewska, E.; Piotrowska, A.; Kreiner, G.; Nalepa, I.; Mika, J. (2017). "Spinal CCL1/CCR8 signaling interplay as a potential therapeutic target - Evidence from a mouse diabetic neuropathy model". International Immunopharmacology 52: 261–271. doi:10.1016/j.intimp.2017.09.021. PMID 28961489. https://pubmed.ncbi.nlm.nih.gov/28961489/. 
  13. ↑ Hill, J. M.; Mervis, R. F.; Avidor, R.; Moody, T. W.; Brenneman, D. E. (1993). "HIV envelope protein-induced neuronal damage and retardation of behavioral development in rat neonates". Brain Research 603 (2): 222–233. doi:10.1016/0006-8993(93)91241-j. PMID 8461978. https://pubmed.ncbi.nlm.nih.gov/8461978/. 
  14. ↑ Socci, D. J.; Pert, C. B.; Ruff, M. R.; Arendash, G. W. (1996). "Peptide T prevents NBM lesion-induced cortical atrophy in aged rats". Peptides 17 (5): 831–837. doi:10.1016/0196-9781(96)00106-4. PMID 8844774. https://pubmed.ncbi.nlm.nih.gov/8844774/. 
  15. ↑ Joy, M. T.; Ben Assayag, E.; Shabashov-Stone, D.; Liraz-Zaltsman, S.; Mazzitelli, J.; Arenas, M.; Abduljawad, N.; Kliper, E. et al. (2019). "CCR5 is a Therapeutic Target for Recovery after Stroke and Traumatic Brain Injury". Cell 176 (5): 1143–1157.e13. doi:10.1016/j.cell.2019.01.044. PMID 30794775. 
  16. ↑ Mondal, S.; Rangasamy, S. B.; Roy, A.; Dasarathy, S.; Kordower, J. H.; Pahan, K. (2019). "Low-Dose Maraviroc, an Antiretroviral Drug, Attenuates the Infiltration of T Cells into the Central Nervous System and Protects the Nigrostriatum in Hemiparkinsonian Monkeys". Journal of Immunology 202 (12): 3412–3422. doi:10.4049/jimmunol.1800587. PMID 31043478. 
  17. ↑ Dallas Buyers Club. Dir. Jean-Marc Vallée. Perf. Matthew McConaughey. Truth Entertainment, Voltage Pictures; Focus Features (US), 2013.
  18. ↑ Marcusson, Jan. "Peptide T a new treatment for psoriasis? A study of nine patients.". https://medicaljournalssweden.se/plugins/generic/pdfJsViewer/pdf.js/web/viewer.html?file=https%3A%2F%2Fmedicaljournalssweden.se%2Factadv%2Farticle%2Fdownload%2F16854%2F20719%2F58802. 



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